高级检索
当前位置: 首页 > 详情页

Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics.

文献详情

资源类型:
Pubmed体系:
机构: [1]Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN [2]Children’s Hospital,Fudan University, Shanghai, China [3]Institutes of Biomedical Sciences,Fudan University, Shanghai, China [4]Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy,West China Hospital,Sichuan University, Chengdu, China [5]Division of Internal Medicine, Graduate Medical Education, MountainView Hospital, University of Nevada, Reno, NV [6]Department of Pathology, St Jude Children’s Research Hospital, Memphis, TN [7]Department of Pediatric Hematology/Oncology, Guangzhou Women andChildren’s Medical Center, Guangzhou, Guangdong, China [8]Department of Biostatistics, College of Public Health and Health Professions and College ofMedicine, University of Florida, Gainesville, FL [9]Institute for Genomic Medicine, Nationwide Children’s Hospital, Columbus, OH [10]Department of Pathology,The Ohio State University, Columbus, OH [11]Department of Pediatrics,The Ohio State University, Columbus, OH [12]Department of Pediatrics, NYU Langone Medical Center, New York, NY [13]Maine Children’s Cancer Program, Scarborough, ME [14]Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine,University of California San Francisco, San Francisco, CA [15]Department of Pediatric Hematology Oncology, University of Texas Southwestern Medical Center,Dallas, TX [16]Cook Children’s Medical Center, Fort Worth, TX [17]Department of Pediatrics, Duke University, Durham, NC [18]Johns Hopkins Medical Institute,Baltimore, MD [19]Division of Hematopathology, Department of Laboratory Medicine, University of Washington, Seattle, WA [20]Unidad Nacional de Oncolog´ıaPedia´ trica, Guatemala City, Guatemala [21]Department of Oncology, St. Jude Children’s Research Hospital,Memphis, TN [22]Hematological Malignancies Program, St. Jude Children’s Research Hospital,Memphis, TN [23]Department of Pediatrics, Perelman School ofMedicine, University of Pennsylvania, Philadelphia, PA [24]Center for Childhood Cancer Research,Children’s Hospital of Philadelphia, Philadelphia, PA [25]Department of Pediatrics, Benioff Children’s Hospital, San Francisco, CA [26]Helen Diller FamilyComprehensive Cancer Center, University of California San Francisco, San Francisco, CA
出处:
ISSN:

摘要:
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Characterized by high levels of Native American ancestry, Hispanics are disproportionally affected by this cancer with high incidence and inferior survival. However, the genetic basis for this disparity remains poorly understood because of a paucity of genome-wide investigation of ALL in Hispanics. Performing a genome-wide association study (GWAS) in 940 Hispanic children with ALL and 681 ancestry-matched non-ALL controls, we identified a novel susceptibility locus in the ERG gene (rs2836365; P = 3.76 × 10-8; odds ratio [OR] = 1.56), with independent validation (P = .01; OR = 1.43). Imputation analyses pointed to a single causal variant driving the association signal at this locus overlapping with putative regulatory DNA elements. The effect size of the ERG risk variant rose with increasing Native American genetic ancestry. The ERG risk genotype was underrepresented in ALL with the ETV6-RUNX1 fusion (P < .0005) but enriched in the TCF3-PBX1 subtype (P < .05). Interestingly, ALL cases with germline ERG risk alleles were significantly less likely to have somatic ERG deletion (P < .05). Our results provide novel insights into genetic predisposition to ALL and its contribution to racial disparity in this cancer. © 2019 by The American Society of Hematology.

基金:
语种:
PubmedID:
中科院(CAS)分区:
出版当年[2019]版:
大类 | 1 区 医学
小类 | 1 区 血液学
最新[2023]版:
大类 | 1 区 医学
小类 | 1 区 血液学
第一作者:
第一作者机构: [1]Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN [3]Institutes of Biomedical Sciences,Fudan University, Shanghai, China
共同第一作者:
通讯作者:
通讯机构: [1]Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN [21]Department of Oncology, St. Jude Children’s Research Hospital,Memphis, TN [22]Hematological Malignancies Program, St. Jude Children’s Research Hospital,Memphis, TN [*1]Hematologic Malignancies Program, Comprehensive Cancer Center, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Pl, MS313, Memphis, TN 38105
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:43389 今日访问量:0 总访问量:3120 更新日期:2024-09-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持:重庆聚合科技有限公司 地址:成都市人民南路四段55号