Volumetric-modulated arc therapy as an alternative to intensity-modulated radiotherapy for primary tumors of advanced non-small-cell lung cancer: A multicenter retrospective analysis based on propensity score matching br
机构:[1]Department of Thoracic Oncology, Affiliated Hospital,[2]Teaching and Research Section of Oncology,[3]The Fourth People's Hospital of Guiyang, Guiyang, China,[4]Sichuan Cancer Hospital and Institute, Sichuan,四川省肿瘤医院[5]The First Clinical Medical College of Lanzhou University, Gansu Provincial Cancer Hospital,[6]Affiliated Cancer Hospital of Guizhou Medical University, Guizhou, China
Purpose: To investigate the effect of volumetric-modulated arc therapy (VMAT) versus intensitymodulated radiotherapy (IMRT) for advanced non-small-cell lung cancer (NSCLC).Methods: Cases in which the primary tumors were treated with IMRT or VMAT as initial intervention in stages III and IV NSCLC patients from September 2008 to March 2020 were retrospectively analyzed. Propensity Score Matching (PSM) was used to assess the efficacy and toxicity of the two radiotherapy techniques.Results: A total of 637 patients were included, out of which 483 cases were treated with IMRT, while 154 received VMAT. A total of 308 patients were selected after PSM. Patients who were having acute radiation esophagitis and pneumonia treated with VMAT had a lower percentage than those treated with IMRT (p < 0.05) before PSM. However, there was no significant difference in grades 3 - 4 toxicity (chi 2 = 2.77, p = 0.096). There were also no significant differences in the primary endpoints between the two groups after PSM (p > 0.05), while for secondary endpoints, all lung V5, and V20, mean lung dose and heart V30, heart V40, mean heart dose in all patients and stage N2 patients in VMAT after PSM wereConclusion: Radiation therapy of A-NSCLC primary tumors using VMAT and IMRT seem to produce similar efficacy. The volume parameters of normal tissues and organs is significantly lower in VMAT, especially in patients with stage N2. Therefore, VMAT may be more beneficial for reducing radiation damage in normal tissues and organs.
基金:
Science and Technology Office of Guizhou Province, China; [Qian ke He]; [2795]
第一作者机构:[1]Department of Thoracic Oncology, Affiliated Hospital,[2]Teaching and Research Section of Oncology,[3]The Fourth People's Hospital of Guiyang, Guiyang, China,
通讯作者:
通讯机构:[1]Department of Thoracic Oncology, Affiliated Hospital,[6]Affiliated Cancer Hospital of Guizhou Medical University, Guizhou, China
推荐引用方式(GB/T 7714):
Liu Jie,Li Tao,Wang Xiaohu,et al.Volumetric-modulated arc therapy as an alternative to intensity-modulated radiotherapy for primary tumors of advanced non-small-cell lung cancer: A multicenter retrospective analysis based on propensity score matching br[J].TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH.2022,21(10):2233-2240.doi:10.4314/tjpr.v21i10.26.
APA:
Liu, Jie,Li, Tao,Wang, Xiaohu,Su, Shengfa,Li, Qingsong...&Lu, Bing.(2022).Volumetric-modulated arc therapy as an alternative to intensity-modulated radiotherapy for primary tumors of advanced non-small-cell lung cancer: A multicenter retrospective analysis based on propensity score matching br.TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH,21,(10)
MLA:
Liu, Jie,et al."Volumetric-modulated arc therapy as an alternative to intensity-modulated radiotherapy for primary tumors of advanced non-small-cell lung cancer: A multicenter retrospective analysis based on propensity score matching br".TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH 21..10(2022):2233-2240