机构：[1]Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China, Chengdu, China.四川省人民医院[2]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China.四川省人民医院[3]Department of Anesthesiology, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.[4]Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.[5]Department of Urology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.四川省人民医院四川省肿瘤医院[6]Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, Guangdong, China.广东省人民医院[7]Renal Department and Nephrology Institute, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Clinical Research Center for Kidney Diseases, Chengdu, Sichuan, China.四川省人民医院
Immunosenescence is the deterioration of the innate and adaptive immune systems associated with aging and is primarily characterized by a reduction in T cell production and accumulation of atypical subsets. Age-related immunological dysfunction leads to impaired immune protection and persistent low-grade chronic inflammation, resulting in a decreased vaccination response and increased vulnerability to infection, cancer, cardiovascular disease, and autoimmune disease in the elderly. As the elderly constitute a growing proportion of the population with renal disease, immunosenescence is a normal aging process that is prevalent among older people. In addition, immunosenescence seems to be more pronounced in patients with kidney diseases than in healthy controls, as shown by severe chronic inflammation, accumulation of immune cells with the senescent phenotype (CD28(-) T cells, CD14(+)CD16(+) monocytes), and proinflammatory cytokine production. Immunosenescence inhibits immunological clearance and renal tissue regeneration, thereby increasing the risk of permanent renal damage, infection, and cardiovascular events in patients with kidney disease, lowering the prognosis, and even influencing the efficacy of renal replacement treatment. Biological drugs (senomorphics and senolytics) target the aging immune system and exert renoprotective effects. This review aims to emphasize the features of immunosenescence and its influence on kidney diseases and immunotherapy, highlighting the future directions of kidney disease treatment using senescence-focused techniques.
基金：
Foundation of Key R&D plan of Sichuan Province [2019YFS0538]; National Natural Science Foundation of China [82200810]; Foundation of Applied Basic Research Project of Sichuan Provincial Science and Technology [2020YJ0179]; Foundation for Young Talent Fund of Sichuan Provincial People's Hospital [2022QN02]; Discipline construction fund of Sichuan Provincial People's Hospital
第一作者机构：[1]Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China, Chengdu, China.[2]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China, Chengdu, China.[2]Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China.[7]Renal Department and Nephrology Institute, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Clinical Research Center for Kidney Diseases, Chengdu, Sichuan, China.
推荐引用方式(GB/T 7714)：
Chi Mingxuan,Tian Zijun,Ma Kuai,et al.The diseased kidney: aging and senescent immunology[J].IMMUNITY & AGEING.2022,19(1):doi:10.1186/s12979-022-00313-9.
医学