Gut microbiota and its metabolites play pivotal roles in host physiology and pathology. Short-chain fatty acids (SCFAs), as a group of metabolites, exert positive regulatory effects on energy metabolism, hormone secretion, immune inflammation, hypertension, and cancer. The functions of SCFAs are related to their activation of transmembrane G protein-coupled receptors and their inhibition of histone acetylation. Though controversial, growing evidence suggests that SCFAs, which regulate inflammation, oxidative stress, and fibrosis, have been involved in kidney disease through the activation of the gut-kidney axis; however, the molecular relationship among gut microbiota-derived metabolites, signaling pathways, and kidney disease remains to be elucidated. This review will provide an overview of the physiology and functions of SCFAs in kidney disease.
基金：
This study was supported by the National Key Research and Development Program of China (No 2016YFC1305403).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区药物化学3 区药学
最新[2023]版：
大类|2 区医学
小类|2 区药物化学2 区药学
第一作者：
第一作者机构：[1]Kidney Research Institute, Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China
通讯作者：
通讯机构：[1]Kidney Research Institute, Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China[*1]Kidney Research Institute, Department of Nephrology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu 610041, China
推荐引用方式(GB/T 7714)：
Lingzhi Li,Liang Ma,Ping Fu.Gut microbiota-derived short-chain fatty acids and kidney diseases.[J].Drug design, development and therapy.2017,11:3531-3542.doi:10.2147/DDDT.S150825.
APA：
Lingzhi Li,Liang Ma&Ping Fu.(2017).Gut microbiota-derived short-chain fatty acids and kidney diseases..Drug design, development and therapy,11,
MLA：
Lingzhi Li,et al."Gut microbiota-derived short-chain fatty acids and kidney diseases.".Drug design, development and therapy 11.(2017):3531-3542
