详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Comparison of Diagnostic Efficacy of [68Ga]Ga-FAPI-04 and [18F]FDG PET/CT for Staging and Restaging of Gastric Cancer

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China. [3]Institute of Nuclear Medicine, Southwest Medical University, Luzhou, China. [4]Department of Geriatric Psychiatry, The Fourth People's Hospital of Chengdu, Chengdu, China. [5]Department of Geriatric Psychiatry, The Clinical Hospital of Chengdu Brain Science Institute, Ministry of Education (MOE) Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.

出处：

DOI：

ISSN：

关键词： [68Ga]Ga-FAPI-04 [18F]-FDG gastric cancer tumor staging PET/CT

摘要：

This study aimed to compare the potential diagnostic efficacy of gallium68-fibroblast-activation protein inhibitor ([68Ga]Ga-FAPI-04) and fluorine18-fluorodeoxyglucose ([18F]-FDG) positron emission tomography-computed tomography (PET/CT) for primary tumors, lymph nodes, and distant metastatic lesions of gastric cancer (GC), and to explore the effects of [68Ga]Ga-FAPI-04 and [18F]-FDG on tumor staging and restaging in GC.This single-center retrospective study (NCT2100044131) was conducted at the Affiliated Hospital of the Southwest Medical University between June 2020 and December 2021. Images of patients with GC who were pathologically confirmed and underwent contemporaneous [18F]-FDG and [68Ga]Ga-FAPI-04 PET/CT within 1 week were analyzed. The diagnostic efficacy of [68Ga]Ga-FAPI-04 PET/CT and [18F]-FDG PET/CT for TNM staging of GC was compared using McNemar test. The maximum standard uptake value (SUVmax) of each lesion in the two imaging types was compared using the Mann-Whitney U test.In total, 25 patients with GC (mean age, 56 ± 12 years) were evaluated. [68Ga]Ga-FAPI-04 PET/CT exhibited higher sensitivity compared to [18F]-FDG PET/CT for detecting primary tumors (18/19 [94.74%] vs. 13/19 [68.42%], χ2 = 6.866, P < 0.01), lymph node metastasis (75/77 [97.40%] vs. 32/77 [41.56%], χ2 = 2.888, P =0.089), and distant metastases (275/283 [97.17%] vs. 122/283 [43.11%], χ2 = 11.858, P < 0.01). [68Ga]Ga-FAPI-04 accumulation was significantly higher than that of [18F]FDG in tumors (median SUVmax, 10.28 vs 3.20; U=59.00, P < 0.01), lymph node metastasis metastases (median SUVmax, 9.20 vs 3.15; U=53.50, P < 0.01), and distant metastases (median SUVmax, 8.00 vs 4.20; U=200.00, P < 0.01). Compared to [18F]-FDG PET/CT, [68Ga]Ga-FAPI-04 PET/CT resulted in new oncological findings in 14/25 patients and corrected tumor staging or restaging in 7/25 patients.Our preliminary results regarding the impact of [68Ga]Ga-FAPI-04 PET/CT on tumor staging highlight the potential of this approach for increasing the accuracy of GC diagnosis, which may facilitate treatment decision-making.Copyright © 2022 Zhang, Wang, Xu, Ding, Li, Liu, Huang, Liu, Du, Zhao, Chen and Qiu.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

第一作者：

第一作者机构： [1]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China. [3]Institute of Nuclear Medicine, Southwest Medical University, Luzhou, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China. [3]Institute of Nuclear Medicine, Southwest Medical University, Luzhou, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Comparison of Diagnostic Efficacy of [68Ga]Ga-FAPI-04 and [18F]FDG PET/CT for Staging and Restaging of Gastric Cancer

文献详情

相关文献