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Comparison of 68Ga-DOTATATE and 18F-FDG PET/CT for tumor staging and primary tumor volume delineation in patients with nasopharyngeal carcinoma

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资源类型：
Pubmed体系：
作者：
Ding Haoyuan[1,2,3] * ; Liang Juan[4] * ; Wang Yudi[1,2,3] ; He Kaixiang[5] ; Liu Lin[1,2,3] ; Liu Ya[1,2,3] ; Chen Yue[1,2,3] ;
机构： [1]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, Sichuan, People’s Republic of China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou 646000, Sichuan, People’s Republic of China. [3]Institute of Nuclear Medicine, Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, Sichuan, People’s Republic of China. [4]Department of Ultrasound, The Affiliated Hospital of Southwest Medical University, No 25. Taiping St, Jiangyang District, Luzhou 646000, Sichuan, People’s Republic of China. [5]Department of Oncology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, Sichuan, People’s Republic of China.
出处：
DOI： 10.1038/s41598-025-00625-y

关键词： 18F-FDG 68Ga-DOTATATE Nasopharyngeal cancer PET/CT

摘要：
This study evaluated the clinical utility of 68Ga-DOTATATE PET/CT compared to 18F-FDG PET/CT for tumor staging and the delineation of primary tumor volume in patients with non-keratinizing nasopharyngeal carcinoma (NPC). Forty-two individuals with pathologically confirmed non-keratinizing NPC were recruited. This study compared the detection rates of primary and metastatic tumors and the accuracy of tumor staging using two PET/CT modalities. Tumor volumes defined on PET scans using the absolute SUV of 2.5 (TH2.5), 40% of the maximum SUV (TH40%), and the relative background-dependent threshold (THbgd) were analyzed in comparison to MRI results. Comparing 68Ga-DOTATATE and 18F-FDG PET/CT, identifying primary tumors (initial detection, 100% vs. 97.3%; recurrent detection, 80.0% vs. 100%) and lymph node metastases (99.0% vs. 100%) were comparable. However, 68Ga-DOTATATE PET/CT detected more skull base bone (100% vs. 96.3%) and intracranial invasion (100% vs. 54.5%) than 18F-FDG, and consequently correctly upwardly adjusted the T-staging in 7 patients. 68Ga-DOTATATE PET/CT detected an equal number of lung metastases (24/24) but more bone metastases (97.8% vs. 84.4%) compared to 18F-FDG PET/CT, yet was less effective for liver metastases (30.4% vs. 100%). Compared with 18F-FDG PET/CT, 68Ga-DOTATATE PET/CT correctly upstaged 5 subjects and downstaged 1 subject in overall staging. Tumor volumes assessed by 68Ga-DOTATATE PET compared to 18F-FDG PET using the three threshold methods demonstrated less variability and higher agreement with MRI. Among the methods, THbgd for lesion segmentation in 68Ga-DOTATATE PET demonstrated the highest confidence level and concordance with MRI (ICC 0.95). In conclusion, 68Ga-DOTATATE PET/CT is a beneficial complement to 18F-FDG PET/CT for NPC staging, with higher accuracy for primary tumor volume delineation.© 2025. The Author(s).

基金：
This work was supported by Luzhou Science and Technology Program (2024JYJ054), National Natural Science Foundation of China (U20A20384), Health Commission of Sichuan Province (21ZD005), Science and Tech­nology Major Project of Gansu Province (23ZDFA014), and Isotope and Drug Innovation Fund of National Engineering Research Center for Isotopes and Drugs (TWSCX-2023-CXJJ-3-1).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
最新[2025]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
第一作者：
第一作者机构： [1]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, Sichuan, People’s Republic of China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou 646000, Sichuan, People’s Republic of China. [3]Institute of Nuclear Medicine, Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, Sichuan, People’s Republic of China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, Sichuan, People’s Republic of China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou 646000, Sichuan, People’s Republic of China. [3]Institute of Nuclear Medicine, Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, Sichuan, People’s Republic of China.
推荐引用方式(GB/T 7714)：
Ding Haoyuan,Liang Juan,Wang Yudi,et al.Comparison of 68Ga-DOTATATE and 18F-FDG PET/CT for tumor staging and primary tumor volume delineation in patients with nasopharyngeal carcinoma[J].Scientific Reports.2025,15(1):16167.doi:10.1038/s41598-025-00625-y.
APA：
Ding Haoyuan,Liang Juan,Wang Yudi,He Kaixiang,Liu Lin...&Chen Yue.(2025).Comparison of 68Ga-DOTATATE and 18F-FDG PET/CT for tumor staging and primary tumor volume delineation in patients with nasopharyngeal carcinoma.Scientific Reports,15,(1)
MLA：
Ding Haoyuan,et al."Comparison of 68Ga-DOTATATE and 18F-FDG PET/CT for tumor staging and primary tumor volume delineation in patients with nasopharyngeal carcinoma".Scientific Reports 15..1(2025):16167

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