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Overexpressed SNRPB/D1/D3/E/F/G correlate with poor survival and immune infiltration in hepatocellular carcinoma

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机构： [1]Department of Clinical Medicine, Shaanxi University of Chinese Medicine Xianyang 712046, Shaanxi, China. [2]Department of Oncology, Fujian Medical University Union Hospital Fuzhou 350001, Fujian, China. [3]Jincheng Institute of Sichuan University Chengdu 610000, Sichuan, China. [4]Department of Orthopaedic Surgery, The First Affiliated Hospital of Fujian Medical University Fuzhou 350005, China. [5]Department of Surgical Oncology Medicine, Second Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712000, Shaanxi, China.

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关键词： Hepatocellular carcinoma snRNPs prognostic biomarker ONCOMINE TCGA GEO

摘要：

Prior reports have indicated that the abnormal expression of small nuclear ribonucleoproteins (snRNPs) genes is related to malignant tumors. However, in hepatocellular carcinoma (HCC), the precise role of snRNPs is not well understood. Therefore, the purpose of this study was to evaluate the prognostic roles of SNRPB/D1/D2/D3/E/F/G and their correlation to immune infiltration in HCC.The study was carried out via the following databases, software, and experimental validation: ONCOMINE, GEPIA2, UALCAN, The Cancer Genome Atlas, Gene Expression Omnibus, ArrayExpress, Kaplan-Meier plotter, cBioPortal, STRING, DAVID 6.8, TIMER, Cytoscape software, and immunohistochemistry experiments.Overexpressed SNRPB/D1/D2/D3/E/F/G proteins were found in HCC tissues. The transcription levels of 7 snRNPs genes were related to the TP53 mutation and tumor grades. SNRPB/D1/D2/D3/F/G expression was significantly correlated with cancer staging, whereas SNRPE was not. Moreover, Kaplan-Meier survival analysis showed that upregulation of SNRPB/D1/D2/E/G was relevant to worse OS in HCC patients, especially in patients with alcohol consumption and those without viral hepatitis. Multivariate Cox regression analysis indicated that expression of SNRPB/D1/D3/E/F/G were independent prognostic factors for unfavorable OS in HCC. In addition, a high mutation rate of snRNPs genes (44%) was also found in HCC. The mRNA expression levels of snRNPs were meaningfully and positively related to six types of infiltrating immune cells (B cells, CD4+ T cells, CD8+ T cells, neutrophil, macrophage, and dendritic cells). Also, SNRPB/D1/G genes were significantly associated with molecular markers of various immune cells in HCC.SNRPB/D1/D3/E/F/G are potential prognostic biomarkers for a short OS in HCC, and SNRPB/D1/G were novel immune therapy targets in HCC patients.AJTR Copyright © 2022.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区医学：研究与实验

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

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第一作者机构： [1]Department of Clinical Medicine, Shaanxi University of Chinese Medicine Xianyang 712046, Shaanxi, China.

通讯作者：

通讯机构： [1]Department of Clinical Medicine, Shaanxi University of Chinese Medicine Xianyang 712046, Shaanxi, China. [5]Department of Surgical Oncology Medicine, Second Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712000, Shaanxi, China. [*1]Department of Surgical Oncology Medicine, Second Affiliated Hospital of Shaanxi University of Chinese Medicine, No. 831. Taiguan Road, Xixian New District, Xianyang 712000, Shaanxi, China.

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