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Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration

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机构: [1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA [2]Department of Orthopaedics, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, PR China [3]WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA
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关键词: Adipose Basement membrane Cartilage Differentiation Nerve Nidogens Vessel

摘要:
Basement membrane proteins are known to guide cell structures, differentiation, and tissue repair. Although there is a wealth of knowledge on the functions of laminins, perlecan, and type IV collagen in maintaining tissue homeostasis, not much is known about nidogen. As a key molecule in the basement membrane, nidogen contributes to the formation of a delicate microenvironment that proves necessary for stem cell lineage-specific differentiation. In this review, the expression of nidogen is delineated at both cellular and tissue levels from embryonic to adult stages of development; the effect of nidogens is also summarized in the context of musculoskeletal development and regeneration, including but not limited to adipogenesis, angiogenesis, chondrogenesis, myogenesis, and neurogenesis. Furthermore, potential mechanisms underlying the role of nidogens in stem cell-based tissue regeneration are also discussed. This concise review is expected to facilitate our existing understanding and utilization of nidogen in tissue engineering and regeneration.© 2021 Chongqing Medical University. Production and hosting by Elsevier B.V.

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出版当年[2022]版:
大类 | 2 区 医学
小类 | 1 区 遗传学 2 区 生化与分子生物学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 生化与分子生物学 2 区 遗传学
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第一作者机构: [1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
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通讯机构: [1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA [3]WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA [*1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, 64 Medical Center Drive, Morgantown, WV 26506-9196, USA
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