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Single kidney transplantation from donors with acute kidney injury: A single-center experience

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机构: [1]Department of Urology, West China Hospital, Sichuan University, Chengdu, China. [2]Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. [3]Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.
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关键词: acute kidney injury pediatric donors single kidney transplantation

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Abstract Introduction: Despite a severe shortage of organ supply, patients are reluctant to accept organs from deceased donors with AKI, let alone from pediatric AKI donors. Methods: We assessed 70 patients who received kidneys from donors with AKI (10 with pediatric and 60 with adult donors) and 176 contemporaneous patients who received kidneys from non‐AKI donors (41 with pediatric and 135 with adult donors) between March 2012 and February 2017 for retrospectively evaluating the clinical outcomes. Results: AKI was defined and staging by the RIFLE criteria and pediatric‐modified RIFLE criteria. Median age was 11.00 years IQR (4.50‐14.00 years), and median weight was 25.00 kg (IQR, 17.00‐45.00 kg) for all pediatric donors. Median follow‐up was 8 months (range, 1‐49 months). Adult AKI group had the highest incidence of DGF (35.0% vs 10%, 9.8%, and 19.3%, P = 0.011). There was a significant increase in DGF in higher AKI stages (Risk: 20.7%, Injury: 46.7%, Failure: 50.0%; P = 0.014) among patients with adult donors. No significant differences were noted in 1‐year (100.0%, 95.1%, 98.3%, and 97.8%; P = 0.751) and 3‐year (100.0%, 95.1%, 98.3%, and 97.8%; P = 0.751) patient survival, and 1‐year (90.0%, 97.6%, 98.3%, and 95.6%; P = 0.535) and 3‐year (90.0%, 97.6%, 98.3%, and 95.6%; P = 0.535) graft survival. Conclusion: Transplants procured from donors with AKI, particularly pediatric ones, could achieve excellent intermediate‐term clinical outcomes and thus potentially ex‐ pand the donor pool.

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出版当年[2019]版:
大类 | 4 区 医学
小类 | 4 区 儿科 4 区 移植
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 儿科 4 区 移植
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第一作者机构: [1]Department of Urology, West China Hospital, Sichuan University, Chengdu, China. [2]Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. [3]Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.
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