机构:[1]Department of Urology, West China Hospital, Sichuan University, Chengdu, China.泌尿外科外科中心新泌尿外科四川省肿瘤医院[2]Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.泌尿外科外科中心新泌尿外科四川省肿瘤医院[3]Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.泌尿外科外科中心新泌尿外科四川省肿瘤医院
Abstract
Introduction: Despite a severe shortage of organ supply, patients are reluctant to
accept organs from deceased donors with AKI, let alone from pediatric AKI donors.
Methods: We assessed 70 patients who received kidneys from donors with AKI (10
with pediatric and 60 with adult donors) and 176 contemporaneous patients who
received kidneys from non‐AKI donors (41 with pediatric and 135 with adult donors)
between March 2012 and February 2017 for retrospectively evaluating the clinical
outcomes.
Results: AKI was defined and staging by the RIFLE criteria and pediatric‐modified
RIFLE criteria. Median age was 11.00 years IQR (4.50‐14.00 years), and median
weight was 25.00 kg (IQR, 17.00‐45.00 kg) for all pediatric donors. Median follow‐up
was 8 months (range, 1‐49 months). Adult AKI group had the highest incidence of
DGF (35.0% vs 10%, 9.8%, and 19.3%, P = 0.011). There was a significant increase in
DGF in higher AKI stages (Risk: 20.7%, Injury: 46.7%, Failure: 50.0%; P = 0.014)
among patients with adult donors. No significant differences were noted in 1‐year
(100.0%, 95.1%, 98.3%, and 97.8%; P = 0.751) and 3‐year (100.0%, 95.1%, 98.3%, and
97.8%; P = 0.751) patient survival, and 1‐year (90.0%, 97.6%, 98.3%, and 95.6%;
P = 0.535) and 3‐year (90.0%, 97.6%, 98.3%, and 95.6%; P = 0.535) graft survival.
Conclusion: Transplants procured from donors with AKI, particularly pediatric ones,
could achieve excellent intermediate‐term clinical outcomes and thus potentially ex‐
pand the donor pool.
语种:
外文
PubmedID:
中科院(CAS)分区:
出版当年[2019]版:
大类|4 区医学
小类|4 区儿科4 区移植
最新[2023]版:
大类|4 区医学
小类|4 区儿科4 区移植
第一作者:
第一作者机构:[1]Department of Urology, West China Hospital, Sichuan University, Chengdu, China.[2]Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.[3]Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
蒋亚梅,宋涂润,刘金鹏,et al.Single kidney transplantation from donors with acute kidney injury: A single-center experience[J].Pediatric Transplantation.2019,23(3):doi:https://doi.org/10.1111/petr.13326.
APA:
蒋亚梅,宋涂润,刘金鹏,王志灵,王显丁...&林涛.(2019).Single kidney transplantation from donors with acute kidney injury: A single-center experience.Pediatric Transplantation,23,(3)
MLA:
蒋亚梅,et al."Single kidney transplantation from donors with acute kidney injury: A single-center experience".Pediatric Transplantation 23..3(2019)