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Safety and efficacy of neoadjuvant treatment with immune checkpoint inhibitors in esophageal cancer: real-world multicenter retrospective study in China.

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收录情况： ◇ SCIE

作者：
Yang Yang[1] * ; Tan Lijie[2] ; Hu Jian[3] ; Li Yin[4] ; Mao Yousheng[4] ; Tian Ziqiang[5] ; Zhang Baihua[6] ; Ma Jianqun[7] ; Li Hecheng[8] ; Chen Chun[9] ; Chen Keneng[10] ; Han Yongtao[11] ; Chen Longqi[12] ; Liu Junfeng[5] ; Yu Bentong[13] ; Yu Zhentao[14,15,*2] ; Li Zhigang[1,*1] ; the Esophageal Cancer Committee of Chinese Anti-Cancer Association ;
机构： [1]Department of Thoracic Surgery, Shanghai ChestHospital, Shanghai Jiao Tong University, Shanghai, P.R.China, [2]Department of Thoracic Surgery, Zhongshan Hospital Affiliated to Fudan University, Shanghai, P. R. China, [3]Department of Thoracic Surgery, The First AffiliatedHospital, Zhejiang University, School of Medicine,Zhejiang, P. R. China, [4]Department of Thoracic Surgery, Cancer Hospital Chinese Academy of Medical Sciences, Beijing, P. R. China, [5]Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P. R. China, [6]Department of Thoracic Surgery, Hunan Cancer Hospital, Changsha, P. R. China, [7]Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, P. R. China, [8]Department of Thoracic Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China, [9]Department of Thoracic Surgery, FujianMedical University UnionHospital, Fuzhou, P. R. China, [10]Department of Thoracic Surgery, BeijingCancer Hospital, Beijing, P. R. China, [11]Department of Thoracic Surgery, Sichuan Cancer Hospital, Chengdu, P. R. China, [12]Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu, P. R. China, [13]Department of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, P. R. China, [14]Department of Thoracic Surgery, Tianjin Medical University Cancer Hospital, Tianjin, P. R. China [15]Department of Thoracic Surgery, Cancer Hospital ChineseAcademy of Medical Sciences, Shenzhen Center, Shenzhen, P. R. China
出处：
DOI： 10.1093/dote/doac031
ISSN：

关键词： esophageal cancer immune checkpoint inhibitors neoadjuvant therapy

摘要：
Immune checkpoint inhibitors (ICIs) have shown a powerful benefit in the neoadjuvant therapy for esophageal cancer, but evidence for its safety and efficacy is limited and may not reflect real-world practice. We retrospectively reviewed the database of treatment-naive patients from 15 esophageal cancer centers in China who received ICIs as neoadjuvant treatment for locally advanced esophageal cancer from May 2019 to December 2020. The primary endpoints were rate and severity of treatment-related adverse events (TRAEs) and immune-related adverse events (irAEs). Secondary endpoints included pathologically complete response (pCR) rate, R0 resection rate, mortality and morbidity. Among the 370 patients, 311 (84.1%) were male with a median age of 63 (range: 30-81) years and stage III or IVa disease accounted for 84.1% of these patients. A total of 299 (80.8%) patients were treated with ICIs and chemotherapy. TRAEs were observed in 199 (53.8%) patients with low severity (grade 1-2, 39.2%; grade 3-4, 13.2%; grade 5, 1.4%), and irAEs occurred in 24.3% of patients and were mostly of grade 1-2 severity (21.1%). A total of 341 (92.2%) patients had received surgery and R0 resection was achieved in 333 (97.7%) patients. The local pCR rate in primary tumor was 34.6%, including 25.8% of ypT0N0 and 8.8% of ypT0N+. The rate of postoperative complications was 41.4% and grade 3 or higher complications occurred in 35 (10.3%) patients. No death was observed within 30 days after surgery, and three patients (0.9%) died within 90 days postoperatively. This study shows acceptable toxicity of neoadjuvant immunotherapy for locally advanced esophageal cancer in real-world data. Long-term survival results are pending for further investigations.© The Author(s) 2022. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

基金：
This study was energetically supported by the Esophageal Cancer Committee of Chinese Anti- Cancer Association and all participating institutions.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 4 区 胃肠肝病学
最新[2023]版：
大类 | 3 区 医学
小类 | 4 区 胃肠肝病学
JCR分区：
出版当年[2022]版：
Q4 GASTROENTEROLOGY & HEPATOLOGY
最新[2023]版：
Q3 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Thoracic Surgery, Shanghai ChestHospital, Shanghai Jiao Tong University, Shanghai, P.R.China,
通讯作者：
通讯机构： [1]Department of Thoracic Surgery, Shanghai ChestHospital, Shanghai Jiao Tong University, Shanghai, P.R.China, [14]Department of Thoracic Surgery, Tianjin Medical University Cancer Hospital, Tianjin, P. R. China [15]Department of Thoracic Surgery, Cancer Hospital ChineseAcademy of Medical Sciences, Shenzhen Center, Shenzhen, P. R. China [*1]Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China. [*2]Department of Thoracic Surgery, Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen 518116, China.
推荐引用方式(GB/T 7714)：
Yang Yang,Tan Lijie,Hu Jian,et al.Safety and efficacy of neoadjuvant treatment with immune checkpoint inhibitors in esophageal cancer: real-world multicenter retrospective study in China.[J].DISEASES OF THE ESOPHAGUS.2022,35(11):doi:10.1093/dote/doac031.
APA：
Yang Yang,Tan Lijie,Hu Jian,Li Yin,Mao Yousheng...&the Esophageal Cancer Committee of Chinese Anti-Cancer Association.(2022).Safety and efficacy of neoadjuvant treatment with immune checkpoint inhibitors in esophageal cancer: real-world multicenter retrospective study in China..DISEASES OF THE ESOPHAGUS,35,(11)
MLA：
Yang Yang,et al."Safety and efficacy of neoadjuvant treatment with immune checkpoint inhibitors in esophageal cancer: real-world multicenter retrospective study in China.".DISEASES OF THE ESOPHAGUS 35..11(2022)

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