Introduction: This study aims to establish a multidisciplinary consensus on the treatment of nasopharyngeal carcinoma (NPC) in China, with a particular focus on the guidelines for the use of immune checkpoint inhibitors (ICIs) to ensure scientific and rational treatment protocols. Methods: The consensus was formulated based on the 'guidelines for the diagnosis and treatment of NPC (2024 edition)' issued by the Chinese Society of Clinical Oncology. The Delphi method was used to collect and consolidate expert opinions. Through repeated solicitation and integration of expert opinions, an expert consensus on combined ICI therapy for NPC was ultimately reached. Additionally, a literature review approach was used to facilitate consensus building. Results: The consensus encompasses the current status of NPC diagnosis and treatment, synthesizing existing clinical evidence to deeply discuss major clinical issues. The primary focus of the consensus is on the clinical practice principles and methods of combinatory ICI therapy. It provides guidelines for patient selection, treatment protocols, and management of adverse events in clinical practice. The consensus emphasizes that multidisciplinary collaboration can further enhance the treatment outcomes and quality of life for NPC patients. Future research needs to continue exploring optimized treatment protocols and predictive biomarkers to achieve more precise personalized therapy. Conclusion: The consensus underscores the role of ICIs in NPC treatment and provides understanding and reference for clinical application. Given the differences in drug approval and availability across countries and the high incidence of NPC in southern China, this consensus particularly focuses on the treatment of Chinese patients.