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The Effects of a Novel Curcumin Derivative Loaded Long-Circulating Solid Lipid Nanoparticle on the MHCC-97H Liver Cancer Cells and Pharmacokinetic Behavior.

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资源类型：
Pubmed体系：
作者：
Wei Yumeng[1,2,3] ; Li Ke[1,2,3] ; Zhao Wenmei[1,2,3] ; He Yingmeng[2,4] ; Shen Hongping[2,5] ; Yuan Jiyuan[2,5] ; Pi Chao[1,2,3] ; Zhang Xiaomei[6] ; Zeng Mingtang[1,2,3] ; Fu Shaozhi[7] ; Song Xinjie[8,9] ; Lee Robert J[10,*1] ; Zhao Ling[2,3,*2] ;
机构： [1]Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China. [2]Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China. [3]Central Nervous System Drug Key Laboratory of Sichuan Province, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China. [4]Department of Pharmacy, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China. [5]Clinical Trial Center, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China. [6]Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, Institute of Medicinal Chemistry of Chinese Medicine, Chongqing Academy of Chinese Materia Medica, Chongqing, 400065, People's Republic of China. [7]Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China. [8]School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, Zhejiang, 310023, People's Republic of China. [9]Department of Food Science and Technology, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 38541, Republic of Korea. [10]Division of Pharmaceutics and Pharmacology, College of Pharmacy, the Ohio State University, Columbus, OH, 43210, USA.
出处：
DOI： 10.2147/IJN.S363237
ISSN：

关键词： curcumin derivative nanoparticle MHCC-97H pharmacokinetics

摘要：
The objective of this study was to develop long-circulating solid lipid nanoparticles (LSLN) containing a novel curcumin (CU) derivative (CU1), to improve CU1's pharmacokinetic behavior and its anti-cancer effects in MHCC-97H liver cancer cells.LSLN loaded with CU1 (CU1-LSLN) was optimized and characterized. The cell biological properties and the anti-cancer mechanism of CU1-LSLN on MHCC-97H cells were evaluated by MTT, flow cytometry, Transwell, and Western blot. CU1-LSLN was further evaluated for pharmacokinetic behavior, biodistribution, and liver toxicity in SD rats.The optimized CU1-LSLN formulation showed the ideal particle size (PS), polydispersity index (PDI), zeta potential (ZP), encapsulation efficiency (EE%), and drug loading (DL%) of 122.10 ± 6.63 nm, 0.19 ± 0.02, -36.30 ± 1.25 mV, 94.98 ± 0.90% and 4.53 ± 0.69%, respectively. X-ray powder diffraction (XRD), differential scanning calorimetry (DSC), and Fourier transform infrared spectrometry (FTIR) indicated that CU1 was well encapsulated by LSLN and existed in amorphous form. Storage stability of CU1-LSLN was up to 180 days with a sustained-release of drug over 96 h. The uptake efficiency of CU1-LSLN to MHCC-97H cells was 3.24 and 2.98 times higher than that of CU and CU1 after treatment for 3 h, which helped to enhance the inhibitive effect of CU1-LSLN on the proliferation, migration, and invasion potential of MHCC-97H cells and increased its ability to promote apoptosis. Meanwhile, the expression levels of NF-κB, COX-2, MMP-2, MMP-9, and uPA decreased significantly. In vivo, CU1-LSLN prolonged the retention time of the drug, the area under the curve (AUC) increased significantly (CU: 69.9-fold, CU1: 85.9-fold), and no significant liver toxicity was observed.CU1-LSLN is a novel preparation with great potential for treating liver cancer.© 2022 Wei et al.

基金：
Cooperative Scientific Research Project of Chunhui Plan of the Ministry of Education of China (No. 2020-703), the Youth Science and Technology Innovation Research Team (No. 2021JDTD0008), and the Basic Research Fund (No. 2020YJ0336, 2020YJ0373) of the Science and Technology Department of Sichuan province of China, Science and Technology Innovation Team from Jiucheng Science and Technology Talent Cultivation Plan in Luzhou City (No. 2019-1). Key Research and Development Projectors of Office of Science & Technology and Talent Work of Luzhou (No. 2021-SYF-26)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 纳米科技
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 纳米科技
第一作者：
第一作者机构： [1]Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China. [2]Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China. [3]Central Nervous System Drug Key Laboratory of Sichuan Province, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
共同第一作者：
通讯作者：
通讯机构： [2]Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China. [3]Central Nervous System Drug Key Laboratory of Sichuan Province, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China. [10]Division of Pharmaceutics and Pharmacology, College of Pharmacy, the Ohio State University, Columbus, OH, 43210, USA. [*1]The Ohio State University, 500 W 12th Ave, Columbus, OH, 43210, USA [*2]Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, No. 182, Chunhui Road, Longmatan District, Luzhou, Sichuan, 646000, People’s Republic of China
推荐引用方式(GB/T 7714)：
Wei Yumeng,Li Ke,Zhao Wenmei,et al.The Effects of a Novel Curcumin Derivative Loaded Long-Circulating Solid Lipid Nanoparticle on the MHCC-97H Liver Cancer Cells and Pharmacokinetic Behavior.[J].International journal of nanomedicine.2022,17:2225-2241.doi:10.2147/IJN.S363237.
APA：
Wei Yumeng,Li Ke,Zhao Wenmei,He Yingmeng,Shen Hongping...&Zhao Ling.(2022).The Effects of a Novel Curcumin Derivative Loaded Long-Circulating Solid Lipid Nanoparticle on the MHCC-97H Liver Cancer Cells and Pharmacokinetic Behavior..International journal of nanomedicine,17,
MLA：
Wei Yumeng,et al."The Effects of a Novel Curcumin Derivative Loaded Long-Circulating Solid Lipid Nanoparticle on the MHCC-97H Liver Cancer Cells and Pharmacokinetic Behavior.".International journal of nanomedicine 17.(2022):2225-2241

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