机构：[1]School of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.[2]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610065, China.四川大学华西医院[3]Research Institute for New Materials Technology, Chongqing University of Arts and Sciences, Chongqing 402160, China.[4]Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.四川大学华西医院
Clearance of bacteria-secreted toxins can be a benefit to treating bacterial infections. In this study, we show a polydiacetylene (PDA) nanoparticle-functionalized microgel for managing topical bacterial infections. These functional microgels with designed shapes and size are precisely fabricated via a digital light processing (DLP)-based 3D bioprinting process. The PDA nanoparticles that can bind and neutralize pore-forming toxins (PFTs) are installed in the microgels by readily mixing within the monomer solution followed by 3D printing. PFTs can diffuse into the microgels and subsequently are captured and neutralized by the PDA nanoparticles. In the mouse model, the local injection of the microgels promotes tissue recovery after bacterial infections. This work presents a PDA nanoparticle-functionalized microgel for topical bacterial infection treatments by removing PFTs, which could inspire future infection treatments.
基金：
This work was supported by the National Key R&D Program
of China (2017YFA0104800), Key Research and Development
Projects of People’s Liberation Army (BWS17J036), 1·3·5
project for disciplines of excellence, West China Hospital,
Sichuan University (ZYYC08007, ZYJC18017), the fundamental
research funds for the central universities
(2018SCUH0010), and the National Natural Science
Foundation of China (21805024).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|1 区化学
小类|1 区高分子科学
最新[2023]版：
大类|1 区化学
小类|1 区高分子科学
第一作者：
第一作者机构：[1]School of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.[2]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610065, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Tao Jie,Xu Xin,Wang Shuai,et al.Polydiacetylene-Nanoparticle-Functionalized Microgels for Topical Bacterial Infection Treatment.[J].ACS macro letters.2019,8(5):563-568.doi:10.1021/acsmacrolett.9b00196.
APA：
Tao Jie,Xu Xin,Wang Shuai,Kang Tianyi,Guo Chaozhong...&Gou Maling.(2019).Polydiacetylene-Nanoparticle-Functionalized Microgels for Topical Bacterial Infection Treatment..ACS macro letters,8,(5)
MLA：
Tao Jie,et al."Polydiacetylene-Nanoparticle-Functionalized Microgels for Topical Bacterial Infection Treatment.".ACS macro letters 8..5(2019):563-568
化学