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The Association Between Vitamin C and Cancer: A Two-Sample Mendelian Randomization Study.

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机构： [1]Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China. [2]Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. [3]Reproductive Center, Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China. [4]Department of Orthopedics, Research Institute of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China.

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关键词： vitamin c cancer GWAS SNP Mendelian randomization

摘要：

In recent years, many studies have indicated that vitamin C might be negatively associated with the risk of cancer, but the actual relationship between vitamin C and cancer remains ambivalent. Therefore, we utilized a two-sample Mendelian randomization (MR) study to explore the causal associations of genetically predicted vitamin C with the risk of a variety of cancers. Single-nucleotide polymorphisms (SNPs) associated with vitamin C at a significance level of p < 5 × 10-8 and with a low level of linkage disequilibrium (LD) (r2 < 0.01) were selected from a genome-wide association study (GWAS) meta-analysis of plasmid concentration of vitamin C consisting of 52,018 individuals. The data of the GWAS outcomes were obtained from United Kingdom Biobank, FinnGen Biobank and the datasets of corresponding consortia. In the inverse-variance weight (IVW) method, our results did not support the causal association of genetically predicted vitamin C with the risk of overall cancer and 14 specific types of cancer. Similar results were observed in sensitivity analyses where the weighted median and MR-Egger methods were adopted, and heterogeneity and pleiotropy were not observed in statistical models. Therefore, our study suggested that vitamin C was not causally associated with the risk of cancer. Further studies are warranted to discover the potential protective and therapeutic effects of vitamin C on cancer, and its underlying mechanisms.Copyright © 2022 Chen, Du, Zhang, Li, Gao, Qin and Wang.

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出版当年[2022]版：

大类 | 3 区生物学

小类 | 3 区遗传学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区遗传学

第一作者：

第一作者机构： [1]Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China. [2]Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. [3]Reproductive Center, Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China.

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通讯作者：

通讯机构： [1]Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China. [2]Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. [3]Reproductive Center, Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China.

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The Association Between Vitamin C and Cancer: A Two-Sample Mendelian Randomization Study.

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