机构：[1]Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center forHematologic Disease, Beijing, China[2]Hematology Research Centre, Division of Experimental Medicine, Department ofMedicine, Imperial College London, London, United Kingdom[3]Department of Hematology, Henan Provincial TumorHospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China河南省肿瘤医院[4]Department of Hematology, NanfangHospital, Southern Medical University, Guangzhou, China[5]Department of Hematology, West China Hospital, SichuanUniversity, Chengdu, China四川大学华西医院[6]Department of Hematology, Xijing Hospital, Air Force Medical University, Xi’an, China[7]StateKey Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology,Chinese Academy of Medical Sciences, Tianjin, China[8]Shanghai Institute of Hematology, State Key Laboratory of MedicalGenomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao TongUniversity School of Medicine, Shanghai, China[9]Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science Center, Beijing, China[10]Department of Hematology, Tongji Hospital, Tongji MedicalCollege, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院[11]Department of Hematology, Tongji MedicalCollege, Union Hospital, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属协和医院
Mental health problems in the general population have been reported during the SARS-CoV-2 pandemic; however, there were rare data in persons with chronic myeloid leukemia (CML). Therefore, we performed a cross-sectional study on mental health evaluated using the 9-item Patient Health Questionnaire (PHQ-9; depression), the 7-item Generalized Anxiety Disorder (GAD-7; anxiety), and the 22-item Impact of Event Scale-Revised (IES-R; distress), including subscales of avoidance, intrusion, and hyper-arousal in persons with CML, non-cancer persons, and immediate family members of persons with cancer as controls (>= 16 years) by an online survey. Data from 3,197 persons with CML and 7,256 controls were collected. In multivariate analyses, CML was significantly associated with moderate to severe depression (OR = 1.6; 95% Confidence Interval [CI], 1.4, 1.9; p < 0.001), anxiety (OR = 1.4 [1.1, 1.7]; p = 0.001), distress (OR = 1.3 [1.1, 1.5]; p < 0.001), and hyper-arousal (OR = 1.5 [1.3, 1.6]; p < 0.001). Moreover, delay in regular monitoring was significantly associated with depression (OR 1.3 [1.0, 1.7]; p = 0.024), anxiety (OR = 1.3 [1.0, 1.8]; p = 0.044), avoidance (OR = 1.2 [1.0, 1.4]; p = 0.017), and intrusion (OR = 1.2 [1.0, 1.4]; p = 0.057); tyrosine kinase-inhibitor dose reduction or discontinuation, depression (OR = 1.9 [1.3, 2.8]; p = 0.001), distress (OR = 2.0 [1.4, 2.8]; p < 0.001), avoidance (OR = 1.6 [1.2, 2.1]; p = 0.004), intrusion (OR = 1.6 [1.1, 2.1]; p = 0.006), and hyper-arousal (OR = 1.3 [1.0, 1.8]; p = 0.088). We concluded that persons with CML during the SARS-CoV-2 pandemic have worse mental health including depression, anxiety, and distress symptoms. Decreasing or stopping monitoring or dose resulted in adverse mental health consequences.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770161, 81970140]
第一作者机构：[1]Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center forHematologic Disease, Beijing, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Bao Mei,Yang Sen,Gale Robert Peter,et al.Mental Health in Persons With Chronic Myeloid Leukemia During the SARS-CoV-2 Pandemic: The Need for Increased Access to Health Care Services[J].FRONTIERS IN PSYCHIATRY.2021,12:doi:10.3389/fpsyt.2021.679932.
APA：
Bao, Mei,Yang, Sen,Gale, Robert Peter,Zhang, Yanli,Liu, Xiaoli...&Jiang, Qian.(2021).Mental Health in Persons With Chronic Myeloid Leukemia During the SARS-CoV-2 Pandemic: The Need for Increased Access to Health Care Services.FRONTIERS IN PSYCHIATRY,12,
MLA：
Bao, Mei,et al."Mental Health in Persons With Chronic Myeloid Leukemia During the SARS-CoV-2 Pandemic: The Need for Increased Access to Health Care Services".FRONTIERS IN PSYCHIATRY 12.(2021)
