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Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.

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机构： [a]Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, Sichuan, 610106, PR China [b]Department of Dermatology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400011, PR China

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关键词： Daidzein MicroRNA TRBP IFN-α Hepatitis C virus (HCV)

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MicroRNAs are emerging as critical endogenous regulators of gene function. Aberrant regulation of microRNAs is associated with various human diseases, most importantly cancer. MicroRNA-122 (miR-122), a liver-specific microRNA, has been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Here, we report that daidzein, a naturally occurring plant isoflavone, inhibits HCV replication and enhances the antiviral effect of IFN-α on HCV therapy by decreasing microRNA-122 levels in vitro without significantly affecting cell growth. Moreover, daidzein was found to inhibit the expression of miR-122 and miR-21 by down-regulating the expression of TRBP, indicating that daidzein is possibly a general inhibitor of the miRNA pathway. Thus, daidzein provides new insights for drug discovery and HCV prevention. Copyright © 2021 Elsevier B.V. All rights reserved.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 4 区病毒学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区病毒学

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第一作者机构： [a]Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, Sichuan, 610106, PR China

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