详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [a]Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, Sichuan, 610106, PR China [b]Department of Dermatology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400011, PR China

出处：

DOI：

ISSN：

关键词： Daidzein MicroRNA TRBP IFN-α Hepatitis C virus (HCV)

摘要：

MicroRNAs are emerging as critical endogenous regulators of gene function. Aberrant regulation of microRNAs is associated with various human diseases, most importantly cancer. MicroRNA-122 (miR-122), a liver-specific microRNA, has been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Here, we report that daidzein, a naturally occurring plant isoflavone, inhibits HCV replication and enhances the antiviral effect of IFN-α on HCV therapy by decreasing microRNA-122 levels in vitro without significantly affecting cell growth. Moreover, daidzein was found to inhibit the expression of miR-122 and miR-21 by down-regulating the expression of TRBP, indicating that daidzein is possibly a general inhibitor of the miRNA pathway. Thus, daidzein provides new insights for drug discovery and HCV prevention. Copyright © 2021 Elsevier B.V. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 3 区医学

小类 | 4 区病毒学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区病毒学

第一作者：

第一作者机构： [a]Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, Sichuan, 610106, PR China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]布鲁氏菌病合并脊柱炎和关节炎的疼痛分值与血清中细胞因子IFN-γ、TNF-α、IL-6、IL-4和IL-2的变化特点 [2]抑制miR-223表达促进巨噬细胞的M2型激活 [3]The quantitative analysis by stem-loop real-time PCR revealed the microRNA-34a, microRNA-155 and microRNA-200c overexpression in human colorectal cancer. [4]Potential role of exosome-associated microRNA panels and in vivo environment to predict drug resistance for patients with multiple myeloma. [5]Mechanisms of microRNA action in rectal cancer radiotherapy [6]A novel serum m7G-harboring microRNA signature for cancer detection [7]MicroRNA variants and colorectal cancer risk: a meta-analysis. [8]microRNA在三阴性乳腺癌转移中的作用 [9]MicroRNA-645 is an oncogenic regulator in colon cancer. [10]Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis.