机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, P. R. China.四川大学华西医院[2]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA.[3]School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Metastasis is deadly and also tough to treat as it is much more complicated than the primary tumour. Anti-metastasis approaches available so far are far from being optimal. A variety of nanomedicine formulae provide a plethora of opportunities for developing new strategies and means for tackling metastasis. It should be noted that individualized anti-metastatic nanomedicines are different from common anti-cancer nanomedicines as they specifically target different populations of malignant cells. This review briefly introduces the features of the metastatic cascade, and proposes a series of nanomedicine-based anti-metastasis strategies aiming to block each metastatic step. Moreover, we also concisely introduce the advantages of several promising nanoparticle platforms and their potential for constructing state-of-the-art individualized anti-metastatic nanomedicines.
基金：
National Nature Science Foundation of China (Grant No. 51102259, 31271021 and 31222023), Distinguished Young Scholars of Sichuan University (Grant No. 2011SCU04B18) and the Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|1 区化学
小类|1 区化学综合
最新[2023]版：
大类|1 区化学
小类|1 区化学：综合
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, P. R. China.[2]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, P. R. China.[2]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
推荐引用方式(GB/T 7714)：
He Qianjun,Guo Shengrong,Qian Zhiyong,et al.Development of individualized anti-metastasis strategies by engineering nanomedicines[J].Chemical Society Reviews.2015,44(17):6258-86.doi:10.1039/c4cs00511b.
APA：
He Qianjun,Guo Shengrong,Qian Zhiyong&Chen Xiaoyuan.(2015).Development of individualized anti-metastasis strategies by engineering nanomedicines.Chemical Society Reviews,44,(17)
MLA：
He Qianjun,et al."Development of individualized anti-metastasis strategies by engineering nanomedicines".Chemical Society Reviews 44..17(2015):6258-86
化学
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