机构：[1]Institute of Digestive Surgery, West China Hospital, Sichuan University Chengdu, Sichuan, China四川大学华西医院[2]Department of General Surgery III, West China Hospital, Sichuan University Chengdu, 37, Guo-Xue-Xiang, Chengdu, 610041 Sichuan, China四川大学华西医院[3]The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan University Chengdu, Sichuan, China四川大学华西医院[4]Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University Chengdu, Sichuan, China四川大学华西医院[5]Department of General Surgery III and Institute of Digestive Surgery, West China Hospital, Sichuan University, 37, Guo-Xue-Xiang, Chengdu, 610041 Sichuan, China四川大学华西医院
We sought to study Toll-like receptor 4 (TLR4) expression on peripheral blood mononuclear cells (PBMCs) during the early stage of human acute pancreatitis (AP). Thirty consecutive patients with acute pancreatitis admitted within 24 hr of onset of abdominal pain were enrolled prospectively in this study. Blood samples were taken by venipuncture at admission and on the third and seventh days after admission. PBMCs were isolated, and TLR4 and CD14 expression on PBMCs was detected by flow cytometer. Serum tumor necrosis factor (TNF)-alpha, interleukin, and lipase were detected simultaneously. Relations among these parameters were analysis. In mild AP, TLR4 expression increased on the first day of admission and then continued to decline for several days. On the seventh day, TLR4 expression was almost normal compared with that of the normal control. The alteration of serum TNF-alpha was coincidence with TLR4. We conclude that mononuclear-macrophages might be ignited through TLR4 (the gatekeeper of the innate immune system) and lead to production of TNF-alpha.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2007]版：
大类|4 区医学
最新[2023]版：
大类|4 区医学
小类|4 区胃肠肝病学
第一作者：
第一作者机构：[1]Institute of Digestive Surgery, West China Hospital, Sichuan University Chengdu, Sichuan, China[2]Department of General Surgery III, West China Hospital, Sichuan University Chengdu, 37, Guo-Xue-Xiang, Chengdu, 610041 Sichuan, China
通讯作者：
通讯机构：[1]Institute of Digestive Surgery, West China Hospital, Sichuan University Chengdu, Sichuan, China[5]Department of General Surgery III and Institute of Digestive Surgery, West China Hospital, Sichuan University, 37, Guo-Xue-Xiang, Chengdu, 610041 Sichuan, China
推荐引用方式(GB/T 7714)：
Li Hong-Guang,Zhou Zong-Guang,Li Yuan,et al.Alterations of Toll-like receptor 4 expression on peripheral blood monocytes during the early stage of human acute pancreatitis.[J].Digestive diseases and sciences.2007,52(8):1973-8.doi:10.1007/s10620-006-9211-4.
APA：
Li Hong-Guang,Zhou Zong-Guang,Li Yuan,Zheng Xue-Lian,Lei Song...&Wang Yong.(2007).Alterations of Toll-like receptor 4 expression on peripheral blood monocytes during the early stage of human acute pancreatitis..Digestive diseases and sciences,52,(8)
MLA：
Li Hong-Guang,et al."Alterations of Toll-like receptor 4 expression on peripheral blood monocytes during the early stage of human acute pancreatitis.".Digestive diseases and sciences 52..8(2007):1973-8
