机构：[1]Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science & Technology of China, Chengdu, China.四川省肿瘤医院[2]Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China.[3]Department of Prenatal Diagnosis, Chengdu Women's & Children's Central Hospital, School of Medicine, University of Electronic Science & Technology of China, Chengdu, China.[4]Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science & Technology of China, Chengdu, China.四川省人民医院[5]Medico-Engineering Cooperation on Applied Medicine Research Center, University of Electronic Science & Technology of China, Chengdu, China.[6]Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science & Technology of China, Chengdu, China.四川省人民医院
Objective: The aim of this study was to investigate the potential association between glaucoma and fecal calprotectin. Methods: A total of 144 glaucomatous patients and 66 healthy controls were enlisted for this study. The fecal calprotectin was assessed using enzyme-linked immunosorbent assay. Results: The median fecal calprotectin levels were significantly elevated in glaucoma (73.67 vs 41.97 μg/g; p < 0.001), primary angle-closure glaucoma (76.85 μg/g; p < 0.001) and primary open-angle glaucoma (69.29 μg/g; p = 0.016) groups compared with controls. A notable proportion of the glaucoma (24%; p < 0.001), primary angle-closure glaucoma (21%; p < 0.001) and primary open-angle glaucoma (24%; p < 0.001) subgroups exhibited highly abnormal fecal calprotectin levels (≥250 μg/g). Conclusion: Elevated fecal calprotectin might indicate potential intestinal inflammation in glaucoma.
第一作者机构：[1]Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science & Technology of China, Chengdu, China.
通讯作者：
通讯机构：[4]Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science & Technology of China, Chengdu, China.[5]Medico-Engineering Cooperation on Applied Medicine Research Center, University of Electronic Science & Technology of China, Chengdu, China.[6]Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science & Technology of China, Chengdu, China.
推荐引用方式(GB/T 7714)：
Wang Zuo,Yuan Hang,Zhu Xiong,et al.Fecal calprotectin as an intestinal inflammation marker is elevated in glaucoma[J].BIOMARKERS IN MEDICINE.2023,465-473.doi:10.2217/bmm-2023-0352.
APA：
Wang Zuo,Yuan Hang,Zhu Xiong,Wang Jinxia,Xiu Wenbo...&Lu Fang.(2023).Fecal calprotectin as an intestinal inflammation marker is elevated in glaucoma.BIOMARKERS IN MEDICINE,,
MLA：
Wang Zuo,et al."Fecal calprotectin as an intestinal inflammation marker is elevated in glaucoma".BIOMARKERS IN MEDICINE .(2023):465-473
