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Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research.

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机构： [1]Department of Integrated Traditional Chinese Medicine and Western Medicine, Sichuan Provincial Pancreatitis Center and West China-Liverpool Biomedical Research Center, West China Hospital, Sichuan University, Chengdu, China, [2]Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China, [3]Liverpool Pancreatitis Research Group, Liverpool University Hospitals National Health Service Foundation Trust and Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom, [4]Malopolska Center of Biotechnology, Jagiellonian University, Krakow, Poland, [5]Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

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关键词： acute pancreatitis animal models pancreatic acinar cells pancreatic stellate cells pancreatic ductal cells translational research

摘要：

Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a substantial morbidity and mortality. Currently there is no specific treatment for the disease, which indicates an ongoing demand for research into its pathogenesis and development of new therapeutic strategies. Due to the unpredictable course of acute pancreatitis and relatively concealed anatomical site in the retro-peritoneum, research on the human pancreas remains challenging. As a result, for over the last 100 years studies on the pathogenesis of this disease have heavily relied on animal models. This review aims to summarize different animal models of acute pancreatitis from the past to present and discuss their main characteristics and applications. It identifies key studies that have enhanced our current understanding of the pathogenesis of acute pancreatitis and highlights the instrumental role of animal models in translational research for developing novel therapies. Copyright © 2020 Yang, Yao, Fu, Mukherjee, Xia, Jakubowska, Ferdek and Huang.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区生理学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区生理学

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第一作者机构： [1]Department of Integrated Traditional Chinese Medicine and Western Medicine, Sichuan Provincial Pancreatitis Center and West China-Liverpool Biomedical Research Center, West China Hospital, Sichuan University, Chengdu, China,

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