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Dietary intake of branched-chain amino acids and survival after colorectal cancer diagnosis.

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机构: [1]Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2]Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. [3]Department of Nutrition, School of Public Health, Anhui Medical University, Hefei, Anhui, China. [4]Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China. [5]Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [6]Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. [7]Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan. [8]Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China. [9]Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. [10]Department of Health Statistics, School of Public Health, China Medical University, Shenyang, Liaoning, China. [11]Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [12]Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [13]Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. [14]Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. [15]Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.
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关键词: branched-chain amino acids colorectal cancer survivorship lifestyle nutrition prognosis

摘要:
Branched-chain amino acids (BCAAs), including leucine, isoleucine and valine, may potentially influence cancer progression by various mechanisms including its role in insulin resistance. However, the association of BCAAs with survival among patients with established colorectal cancer (CRC) remains unclear. We evaluated the associations between postdiagnostic BCAA intake with CRC-specific mortality and overall mortality among 1674 patients with nonmetastatic CRC in the Nurses' Health Study and the Health Professionals Follow-up Study. Patients completed a validated food frequency questionnaire. Multivariable hazard ratios (HRs) were calculated using Cox proportional-hazards regression model after adjustment for tumor characteristics and potential confounding factors. Comparing the highest with the lowest quartile intake of postdiagnostic total BCAA, the multivariable HRs were 1.18 (95% confidence interval [CI], 0.75-1.85, P for trend = .46 across quartiles) for CRC-specific mortality and 1.30 (95% CI, 1.01-1.69, P for trend = .04) for all-cause mortality. The multivariable HRs (the highest vs the lowest quartile) for all-cause mortality were 1.33 (95% CI, 1.03-1.73, Ptrend = .02) for valine, 1.28 (95% CI, 0.99-1.66, P for trend = .05) for leucine and 1.25 (95% CI, 0.96-1.61, P for trend = .06) for isoleucine. No statistically significant associations with each of the BCAA intake were observed for CRC-specific mortality (all P for trend > .30). Our findings suggest positive associations between higher intake of dietary BCAAs and risk of all-cause mortality in CRC patients. These findings need to be confirmed and potential mechanisms underlying this association need to be elucidated. © 2020 UICC.

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第一作者:
第一作者机构: [1]Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2]Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
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通讯机构: [1]Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [6]Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. [*1]Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Room 453, Boston, MA 02115.
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