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A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma.

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资源类型：
Pubmed体系：
作者：
Li Longqing[1,2] ; Li Zhuangzhuang[1,2] ; He Xuanhong[1,2] ; Wang Yang[1,2] ; Lu Minxun[1,2] ; Gong Taojun[1,2] ; Chang Qing[1] ; Lin Jingqi[1] ; Luo Yi[1,2] ; Min Li[1,2] ; Zhou Yong[1,2] ; Tu Chongqi[1,2] ;
机构： [1]Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China. [2]Bone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
出处：
DOI： 10.3389/fnut.2022.883308
ISSN：

关键词： osteosarcoma nutrition metabolism prognosis hematology

摘要：
Osteosarcoma is a primary malignant bone tumor with high metastatic potential. To date, achieving long-term survival of osteosarcoma patients remains a difficult task. Metabolic reprogramming has emerged as a new hallmark of cancer. However, studies on the prognostic value of hematological markers related to nutritional and metabolism in cancer patients are limited and contradictory. In this retrospective study, we extensively collected 16 hematological markers related to nutritional and metabolism in 223 osteosarcoma patients. A nutritional metabolism related prognostic scoring system (NMRS) in patients with osteosarcoma was constructed by least absolute contraction and selection operator (LASSO) cox regression analysis. Compared with individual hematological indicators, NMRS has stronger predictive power (training set: 0.811 vs. 0.362-2.638; validation set: 0.767 vs. 0.333-0.595). It is an independent prognostic factor for the survival of patients with osteosarcoma [HR: 1.957 (1.375-2.786) training set; HR: 3.146 (1.574-6.266) validation set]. NMRS-based nomograms have good and stable predictive power. NMRS facilitates further risk stratification of patients with the same clinical characteristics.Copyright © 2022 Li, Li, He, Wang, Lu, Gong, Chang, Lin, Luo, Min, Zhou and Tu.

基金：
Science and Technology Research Program of Sichuan Province (2020YFS0036), 135 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18036), the Fundamental Research Funds for the Central Universities (20826041E4071), Post-Doctor Research Project, West China Hospital, Sichuan University (20HXBH136), and Project funded by China Postdoctoral Science Foundation (2021M702342).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 农林科学
小类 | 2 区 营养学
最新[2023]版：
大类 | 2 区 农林科学
小类 | 3 区 营养学
第一作者：
第一作者机构： [1]Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China. [2]Bone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China. [2]Bone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
推荐引用方式(GB/T 7714)：
Li Longqing,Li Zhuangzhuang,He Xuanhong,et al.A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma.[J].Frontiers in nutrition.2022,9:883308.doi:10.3389/fnut.2022.883308.
APA：
Li Longqing,Li Zhuangzhuang,He Xuanhong,Wang Yang,Lu Minxun...&Tu Chongqi.(2022).A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma..Frontiers in nutrition,9,
MLA：
Li Longqing,et al."A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma.".Frontiers in nutrition 9.(2022):883308

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