机构：[1]Department of Hepatobiliary and Pancreas Surgery The 2nd Clinical Medical College (Shenzhen People’s Hospital) of Jinan University Shenzhen 518020, P. R. China深圳市康宁医院深圳市人民医院深圳医学信息中心[2]Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan University Guangzhou, Guangdong 510632, P. R. China[3]Shenzhen Second People’s Hospital The First Affiliated Hospital of Shenzhen University and Collaborative Innovation Center for Optoelectronic Science and Technology of Shenzhen University Shenzhen 518060, P. R. China深圳市第二人民医院深圳医学信息中心[4]Shenzhen International Institute for Biomedical Research Shenzhen 518116, P. R. China[5]Key Laboratory of Marine Chemistry Theory and Technology (Ocean University of China) Ministry of Education Qingdao 266100, P. R. China[6]Department of Chemistry Korea University Seoul 02841, Korea[7]Department of Microbiology Tumor and Cell Biology Karolinska Institute Stockholm 17177, Sweden[8]Department of Cellular and Genetic Medicine School of Basic Medical Sciences Fudan University Shanghai 200032, P. R. China[9]School of Traditional Chinese Medicine Jinan University Guangzhou, Guangdong 510632, P. R. China[10]Department of Respiratory Disease The Fourth Hospital of Jinan Jinan, Shandong 250031, P. R. China[11]Department of Pancreatic Surgery West China School of Medicine Sichuan University Chengdu 610041, P. R. China[12]State Key Laboratory of Respiratory Disease Department of Infection and Immunity Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Guangdong 510530, P. R. China[13]University of Chinese Academy of Sciences Beijing 100049, P. R. China[14]Department of clinical laboratory Shenzhen Sun Yat-sen Cardiovascular Hospital Shenzhen, Guangdong 518020, P. R. China深圳市康宁医院深圳医学信息中心中国医学科学院阜外医院深圳医院[15]Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis Shenzhen, Guangdong 518020, P. R. China
Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia-induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT-photosensitizer and on-demand designed anticancer prodrug SN38-Nif, which is released and activated by photothermia and tumor-overexpressed esterase. In vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by specifically targeting malignant cells, chemotherapy/hyperthermia-induced tumor inflammation, and angiogenesis. In mouse models, the ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61435010, 61575089, U1803128]; Science and Technology Innovation Commission of Shenzhen [KQTD2015032416270385, JCYJ20150625103619275, JCYJ20180305124854790, KQJSCX20180321164801762]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M610540, 2018T110892, 2018M643364]; Start-up Fund of Natural Science Foundation of Guangdong Province, China [2018A030310040, 2018A030310500]; Natural Science Foundation of Shandong Province, ChinaNatural Science Foundation of Shandong Province [ZR2016BB33]; CRI project from the National Research Foundation of Korea [2018R1A3B1052702]; Taishan Scholar Project of Shandong Province [tsqn201909054]
第一作者机构：[1]Department of Hepatobiliary and Pancreas Surgery The 2nd Clinical Medical College (Shenzhen People’s Hospital) of Jinan University Shenzhen 518020, P. R. China[2]Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan University Guangzhou, Guangdong 510632, P. R. China
推荐引用方式(GB/T 7714)：
Quan Liu,Zhongjian Xie,Meng Qiu,et al.Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer[J].ADVANCED SCIENCE.2020,7(24):doi:10.1002/advs.202001191.
APA：
Quan Liu,Zhongjian Xie,Meng Qiu,Inseob Shim,Yunlong Yang...&Yihai Cao.(2020).Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.ADVANCED SCIENCE,7,(24)
MLA：
Quan Liu,et al."Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer".ADVANCED SCIENCE 7..24(2020)
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