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Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway.

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机构： [1]School of Medicine, Nankai University, Tianjin, [2]Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, [3]Department of Immunology, School of Basic Medicine, Peking Union Medical College, Beijing, People’s Republic of China [4]Immunology Research Center, National Health Research Institutes, Miaoli, Taiwan [5]Department of Cell and Molecular Biology, Scripps Research Institute, La Jolla, California

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关键词： Ifit1 LPS fatal hepatitis TNF-α JNK

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Treatment of mice with lipopolysaccharide (LPS) and the liver-specific transcriptional inhibitor D-(+)-galactosamine (GalN) induces fatal hepatitis, which is mediated by tumor necrosis factor α (TNF-α) and characterized by massive hepatic apoptosis. Previous studies suggest that GalN increases the sensitivity to LPS/TNF-α, probably by blocking the transcription of protective factors, but the identity of most of these factors is still unclear. Here, we report that Ifit1 protects against LPS/GalN-induced fatal hepatitis. Forced expression of Ifit1 in hepatocytes significantly diminished TNF-α-mediated apoptosis. Moreover, targeted expression of Ifit1 in the liver by recombinant adeno-associated virus serotype 8 protected mice from LPS/GalN-induced lethal hepatitis, which was associated with the inhibition of TNF-α-mediated activation of the c-Jun N-terminal kinase (JNK)-Bim cascade. Furthermore, Ifit1 bound to a scaffolding protein Axin and inhibited its function to mediate JNK activation. Together, our data demonstrate that Ifit1 is a novel protective factor that inhibits LPS/GalN-induced (TNF-α-mediated) fatal hepatitis, suggesting that Ifit1 is a potential therapeutic target for treatment of inflammatory liver diseases. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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出版当年[2015]版：

大类 | 2 区

医学

小类 | 2 区免疫学 2 区传染病学 2 区微生物学

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区免疫学 2 区传染病学 2 区微生物学

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第一作者机构： [1]School of Medicine, Nankai University, Tianjin, [2]Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University,

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通讯机构： [1]School of Medicine, Nankai University, Tianjin, [*1]School of Medicine, Nankai University, Tianjin 300071, PR China

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