个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Phosphoesterase complex modulates microflora and chronic inflammation in rats with alcoholic fatty liver disease.

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Di Ma[a] * ; Jie Hu[b] * ; Wenqi Xu[c,d] ; Yan Wang[c,d] ; Juan Wang[c,d] ; Liang Li[c,d] ; Sheng Wang[c,d] ; Huiping Zhou[f] ; Yuhua Li[e,f,*1] ; Li Liu[c,d,*2] ;
机构： [a]Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China [b]Qingdao Huanghai Pharmaceutical Co., Ltd, Shangdong 266101, China [c]China State Institute of Pharmaceutical Industry, Shanghai 200040, China [d]State Key Laboratory of New Drug & Pharmaceutial Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China [e]Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Southwest Medial University, Luzhou 646000, Sichuan, China [f]Department of Pharmacology, School of Pharmacy, Guilin Medial University, Guilin 541001, Guangxi, China [8]Department of Pharmacology, School of Pharmacy, Guilin Medial University, Guangxi 541001, China
出处：
DOI： 10.1016/j.lfs.2020.118509
ISSN：

关键词： Phosphoesterase complex Microflora Gut barrier Chronic inflammation Alcoholic fatty liver disease

摘要：
Phosphoesterase complex (Pho), a major active component of barley malt, has been demonstrated to be clinically effective in relieving alcoholic fatty liver disease (AFLD), and several lines of evidence have suggested that microbial dysbiosis, caused by chronic alcohol overconsumption, plays a key role in the progression of AFLD. The current study aimed to investigate the modulatory effect of Pho on gut microflora. The microbiota diversity, determined via detection of the V4 region of 16S rDNA genes, was analyzed in rats fed the Lieber-Decarli diet. Gut permeability was evaluated via mucus layer staining. Dysbiosis-associated chronic inflammation was investigated by observing the expression of the following inflammatory molecules in the liver: tumor necrosis factor α (TNF-α), monocyte chemotactic protein 1 (MCP-1), chemokine (C-X-C motif) ligand 1 (CXCL-1) and interleukin 1 beta (IL-1β). Pyrosequencing revealed that the gut microbiota in Pho-treated rats was different from that of AFLD rats at both the phylum and genus levels. In addition, Pho significantly alleviated dysbiosis-associated disruption of gut permeability and inflammation, increased mucus layer thickness and downregulated TNF-α, MCP-1, CXCL-1 and IL-1β expression. In summary, the current results revealed that the microflora, gut barrier and chronic inflammation in AFLD may be modulated by Pho. Copyright © 2020 Elsevier Inc. All rights reserved.

基金：
This work was supported by the Shanghai Sailing Program [grant no. 17YF1419000].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 医学：研究与实验 3 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验 2 区 药学
第一作者：
第一作者机构： [a]Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
共同第一作者：
通讯作者：
通讯机构： [c]China State Institute of Pharmaceutical Industry, Shanghai 200040, China [d]State Key Laboratory of New Drug & Pharmaceutial Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China [e]Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Southwest Medial University, Luzhou 646000, Sichuan, China [f]Department of Pharmacology, School of Pharmacy, Guilin Medial University, Guilin 541001, Guangxi, China [*1]Department of Microbial and Biochemical Pharmacy, Southwest Medial University, Luzhou 646000, Sichuan, China [*2]State Key Laboratory of New Drug & Pharmaceutical, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200437, China
推荐引用方式(GB/T 7714)：
Di Ma,Jie Hu,Wenqi Xu,et al.Phosphoesterase complex modulates microflora and chronic inflammation in rats with alcoholic fatty liver disease.[J].Life sciences.2020,262:118509.doi:10.1016/j.lfs.2020.118509.
APA：
Di Ma,Jie Hu,Wenqi Xu,Yan Wang,Juan Wang...&Li Liu.(2020).Phosphoesterase complex modulates microflora and chronic inflammation in rats with alcoholic fatty liver disease..Life sciences,262,
MLA：
Di Ma,et al."Phosphoesterase complex modulates microflora and chronic inflammation in rats with alcoholic fatty liver disease.".Life sciences 262.(2020):118509

相关文献

[1]Bidirectional associations among gallstone disease, non-alcoholic fatty liver disease, kidney stone disease [2]Regional difference in the susceptibility of non-alcoholic fatty liver disease in China [3]Dysregulated m6A Modification Promotes Lipogenesis and Development of Non-alcoholic Fatty Liver Disease and Hepatocellular Carcinoma. [4]Global liver disease burdens and research trends: Analysis from a Chinese perspective [5]The hepato-ovarian axis: genetic evidence for a causal association between non-alcoholic fatty liver disease and polycystic ovary syndrome [6]Discovery of a Potent 9-Deazaxanthine-based Agent for the Treatment of Obesity-Related Non-alcoholic Fatty Liver Disease. [7]Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells [8]Non-alcoholic fatty liver disease is associated with immune checkpoint inhibitor-based treatment response in patients with non-small cell lung cancer with liver metastases [9]Estimating global prevalence, incidence, and outcomes of non-alcoholic fatty liver disease from 2000 to 2021: systematic review and meta-analysis [10]Editorial: Liver diseases and programmed cell death

资源点击量：54684 今日访问量：0 总访问量：4646 更新日期：2025-03-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持：重庆聚合科技有限公司 地址：成都市人民南路四段55号