机构：[1]Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan Institute of Metabolic Disease, Fudan University, Shanghai, China[2]Department of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[3]Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine Tumors of Ministry of Shanghai, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China[4]Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, China[5]Department of Endocrinology and Metabolism, Shenzhen University General Hospital, Shenzhen, China深圳大学总医院深圳市康宁医院深圳医学信息中心[6]Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China[7]Department of Endocrinology and Metabolism, The Third Central Hospital of Tianjin, Tianjin, China[8]Department of Endocrinology and Metabolism, The First Affiliated Hospital of Kunming Medical University, Kunming, China昆明医科大学附属第一医院[9]Department of Endocrinology and Metabolism, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, Jiangsu, China[10]Department of Endocrinology and Metabolism, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China[11]Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China[12]Department of Endocrinology and Metabolism, Zhongda Hospital Affiliated to Southeast University Medical School, Nanjing, China[13]Endocrine Testing Center, General Hospital of Ningxia Medical University, Yinchuan, China[14]Department of Endocrinology, Qilu Hospital of Shandong University, Qingdao, China[15]Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China[16]Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[17]Department of Clinical Nutrition, Zhongshan Hospital, Center of Clinical Epidemiology, EBM of Fudan University, Fudan University, Shanghai, China
Introduction Non-alcoholic fatty liver disease (NAFLD) is a global health problem with high geographic heterogeneity. We aimed to investigate regional-specific concomitant rate of NAFLD and quantitative relationship between liver fat content (LFC) and glucose metabolism parameters in representative clinical populations from six provinces/municipalities of China. Research design and methods A total of 2420 eligible Han Chinese were enrolled consecutively from 10 clinics of obesity, diabetes and metabolic diseases located at six provinces/municipalities of China, and divided into North (Tianjin, Shandong and Heilongjiang) and South (Shanghai, Jiangsu and Henan) groups according to their geographical latitude and proximity of NAFLD concomitant rate. LFC was assessed by a quantitative ultrasound method. Multivariate regression models and analysis of covariance were used to assess the regional difference in the risk of NAFLD. Results The concomitant rate of NAFLD was 23.3%, 44.0% and 55.3% in individuals with normal glucose tolerance (NGT), pre-diabetes and diabetes, respectively. A higher concomitant rate of NAFLD was found in the participants from the North comparing with the South group, regardless of glucose metabolism status (34.7% vs 16.2% in NGT, 61.5% vs 34.7% in pre-diabetes and 67.1% vs 48.1% in diabetes). This regional difference remained significant after adjustment for age, gender, alcohol drinking, cigarette smoking, confounding metabolic parameters and liver enzymes. For any given blood glucose, participants from the North had higher LFC than those from the South group. Conclusions Half of Han Chinese with pre-diabetes/type 2 diabetes had NAFLD, and the individuals from the North cities were more susceptible to NAFLD.
基金：
This work was supported by the financial support of National Natural
Science Foundation of China (81471073 to HB).
第一作者机构：[1]Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan Institute of Metabolic Disease, Fudan University, Shanghai, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Mingfeng Xia,Xiaoyang Sun,Lili Zheng,et al.Regional difference in the susceptibility of non-alcoholic fatty liver disease in China[J].BMJ OPEN DIABETES RESEARCH & CARE.2020,8(1):doi:10.1136/bmjdrc-2020-001311.
APA：
Mingfeng Xia,Xiaoyang Sun,Lili Zheng,Yufang Bi,Qiang Li...&Hua Bian.(2020).Regional difference in the susceptibility of non-alcoholic fatty liver disease in China.BMJ OPEN DIABETES RESEARCH & CARE,8,(1)
MLA：
Mingfeng Xia,et al."Regional difference in the susceptibility of non-alcoholic fatty liver disease in China".BMJ OPEN DIABETES RESEARCH & CARE 8..1(2020)
