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The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer(Open Access)

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收录情况： ◇ SCIE

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机构： [1]State Key Laboratory of Oral Diseases, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China [2]Department of Head and Neck Surgery, Sichuan Cancer Center, School of Medicine, Sichuan Cancer Hospital & Institute, University of Electronic Science and Technology of China, Chengdu, China [3]State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China

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关键词： head and neck immunotherapy PD-1 PD-L1 prognostic

摘要：

Over the past 10 years, cancer immunotherapy has made significant progress in multiple cancer types and has been gradually been applied to clinical cancer care, in which the programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is one of the most attractive targets. Compared with traditional therapies, the emerging PD-1/PD-L1 blockade immunotherapy exhibited more satisfactory curative effects and lower toxicity for patients with advanced head and neck squamous cell carcinoma (HNSCC). This review analyzes the expression characteristics and clinical significance of PD-1/PD-L1 in HNSCC, the immunosuppressive roles of tumor cell and stromal cell expressing PD-1/PD-L1 in this disease, and presents the development landscape of PD-1/PD-L1 inhibitors, which may provide new curative alternatives for recurrent or metastatic HNSCC. © Copyright © 2020 Qiao, Jiang, Pang, Huang, Tang, Liang and Tang.

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出版当年[2020]版：

大类 | 2 区

医学

小类 | 3 区免疫学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区免疫学

JCR分区：

出版当年[2020]版：

Q1 IMMUNOLOGY

最新[2023]版：

Q1 IMMUNOLOGY

影响因子： 5.7 最新[2023版] 6.8 最新五年平均 7.561 出版当年[2020版] 7.624 出版当年五年平均 5.085 出版前一年[2019版] 8.787 出版后一年[2021版]

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第一作者机构： [1]State Key Laboratory of Oral Diseases, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China

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