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Evolving perspectives regarding the role of the PD-1/PD-L1 pathway in gastric cancer immunotherapy

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资源类型：
Pubmed体系：
作者：
Yu Xianzhe[1,2] * ; Zhai Xiaoqian[1] * ; Wu Juan[3] * ; Feng Qingbo[4] ; Hu Chenggong[5] ; Zhu Lingling[1,*1] ; Zhou Qinghua[1,*1] ;
机构： [1]Department of Medical Oncology, Cancer Center & Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China [2]Department of Gastrointestinal Surgery, Chengdu Second People’s Hospital, No. 10 Qinyun Nan Street, Chengdu, Sichuan Province, People’s Republic of China [3]Out-patient Department, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China [4]Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Affiliated Digestive Hospital of Zunyi Medical University, Zunyi, Guizhou Province, People’s Republic of China [5]Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
出处：
DOI： 10.1016/j.bbadis.2023.166881
ISSN：

关键词： Gastric cancer PD-1/PD-L1 Immune checkpoint inhibitors Immunotherapy

摘要：
Gastric cancer (GC) is an increasing global health problem and is one of the leading cancers worldwide. Traditional therapies, such as radiation and chemotherapy, have made limited progress in enhancing their efficacy for advanced GC. The development of immunotherapy for advanced GC has considerably improved with a deeper understanding of the tumor microenvironment. Immunotherapy using checkpoint inhibitors is a new therapeutic option that has made substantial advances in the treatment of other malignancies and is increasingly used in other clinical oncology treatments. Particularly, therapeutic antibodies targeting the programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway have been effectively used in the clinical treatment of cancer. Monoclonal antibodies blocking the PD-1/PD-L1 pathway have been developed for cancer immunotherapy to enhance T cell function to restore the immune response and represent a breakthrough in the treatment of GC. This review provides an outline of the progress of PD-1/PD-L1 blockade therapy and its expression characteristics and clinical application in advanced GC.Copyright © 2023. Published by Elsevier B.V.

基金：
National Natural Science Foundation of China (No. 82202989); the China Postdoctoral Science Foundation (No. 2022M722279, China); the Sichuan Science and Technology Program (No. 2023YFS0163, China); Postdoctoral Research Project of West China Hospital, Sichuan University, Chengdu, China (No. 2021HXBH045); Fundamental Research Funds for the Central Universities (No. 2022SCU1206); and Sichuan University Postdoctoral Interdisciplinary Innovation Fund (awarded to LZ, China).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 生物物理
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 生物物理
第一作者：
第一作者机构： [1]Department of Medical Oncology, Cancer Center & Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China [2]Department of Gastrointestinal Surgery, Chengdu Second People’s Hospital, No. 10 Qinyun Nan Street, Chengdu, Sichuan Province, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Medical Oncology, Cancer Center & Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China [*1]Department of Medical Oncology, Cancer Center & Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China.
推荐引用方式(GB/T 7714)：
Yu Xianzhe,Zhai Xiaoqian,Wu Juan,et al.Evolving perspectives regarding the role of the PD-1/PD-L1 pathway in gastric cancer immunotherapy[J].Biochimica et biophysica acta. Molecular basis of disease.2023,1870(1):166881.doi:10.1016/j.bbadis.2023.166881.
APA：
Yu Xianzhe,Zhai Xiaoqian,Wu Juan,Feng Qingbo,Hu Chenggong...&Zhou Qinghua.(2023).Evolving perspectives regarding the role of the PD-1/PD-L1 pathway in gastric cancer immunotherapy.Biochimica et biophysica acta. Molecular basis of disease,1870,(1)
MLA：
Yu Xianzhe,et al."Evolving perspectives regarding the role of the PD-1/PD-L1 pathway in gastric cancer immunotherapy".Biochimica et biophysica acta. Molecular basis of disease 1870..1(2023):166881

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