Accuracy of transvaginal sonoelastography for differential diagnosis between malignant and benign cervical lesions: A systematic review and meta-analysis.
机构：[1]Department of Ultrasound, the Affiliated Cancer Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan CancerHospital and Institute, Chengdu, China四川省人民医院四川省肿瘤医院[2]Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[3]Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China[4]Department of Thoracic Surgery, the Affiliated Cancer Hospital, School of Medicine, University of Electronic Science and Technology of China, SichuanCancer Hospital and Institute, Chengdu, China四川省人民医院[5]Department of Gynecological Oncology, the Affiliated Cancer Hospital, School of Medicine, University of Electronic Science and Technology of China,Sichuan Cancer Hospital and Institute, Chengdu, China四川省人民医院四川省肿瘤医院[6]Department of Bioinformatics, Basic Medical College of Chongqing Medical University, Chongqing, China
To evaluate the performance of transvaginal sonoelastography (TVSE) for differential diagnosis between malignant and benign cervical lesions using a meta-analysis.An independent literature search was conducted on the English medical database, including PubMed, Embase and Medline, Cochrane Library, Web of Science, and OVID. The diagnostic accuracy of TVSE was compared with that of histopathology, which is the gold reference standard for diagnosis. The accuracy of TVSE was assessed by calculating the pooled sensitivity, specificity, diagnostic odds ratio, and area under the curve (AUC). The imaging mechanisms, assessment methods, and QUADAS scores were assessed with a meta-regression analysis. A Deeks funnel plot was performed for evaluating publication bias.Six eligible studies reported a total sample of 615 cervical lesions (415 cancers, 200 benign lesions). TVSE showed a pooled diagnostic odds ratio of 21.42 (95% CI 13.65-33.61), sensitivity of 0.87 (95% CI 0.84-0.90), specificity of 0.79 (95% CI 0.72-0.84), and an AUC of 0.892 (Q* = 0.822). The results of the meta-regression analysis showed that the imaging mechanism (P = .253), the assessment method (P = .279), or QUADAS score (P = .205) did not affect the study heterogeneity.TVSE has a relatively high and satisfactory value for differential diagnosis between malignant and benign cervical lesions. The diagnostic performance of strain elastography and shear wave elastography were similar and good. However, to accommodate heterogeneity and publication bias, high-quality studies are required to further comparative effectiveness analyses to verify the efficacy of ultrasound detection.
基金：
This work was supported by the National Natural Science Foundation of China[81902670].
第一作者机构：[1]Department of Ultrasound, the Affiliated Cancer Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan CancerHospital and Institute, Chengdu, China[2]Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China[3]Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China[*1]Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China.[*2]Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Yi Zhu,Xue-Feng Leng,Guo-Nan Zhang,et al.Accuracy of transvaginal sonoelastography for differential diagnosis between malignant and benign cervical lesions: A systematic review and meta-analysis.[J].CANCER MEDICINE.2020,9(21):7943-7953.doi:10.1002/cam4.3424.
APA：
Yi Zhu,Xue-Feng Leng,Guo-Nan Zhang,Zi-Yi Huang,Li Qiu&Wei Huang.(2020).Accuracy of transvaginal sonoelastography for differential diagnosis between malignant and benign cervical lesions: A systematic review and meta-analysis..CANCER MEDICINE,9,(21)
MLA：
Yi Zhu,et al."Accuracy of transvaginal sonoelastography for differential diagnosis between malignant and benign cervical lesions: A systematic review and meta-analysis.".CANCER MEDICINE 9..21(2020):7943-7953
