机构：[1]Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, USA[2]Laboratory of Molecular and Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education at Sichuan University, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China
Aerobic glycolysis or the Warburg effect contributes to cancer cell proliferation; however, how this glucose metabolism pathway is precisely regulated remains elusive. Here we show that receptor-interacting protein 1 (RIP1), a cell death and survival signaling factor, regulates mitochondrial oxidative phosphorylation and aerobic glycolysis. Loss of RIP1 in lung cancer cells suppressed peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) expression, impairing mitochondrial oxidative phosphorylation and accelerating glycolysis, resulting in spontaneous DNA damage and p53-mediated cell proliferation inhibition. Thus, although aerobic glycolysis within a certain range favors cancer cell proliferation, excessive glycolysis causes cytostasis. Our data suggest that maintenance of glycolysis by RIP1 is pivotal to cancer cell energy homeostasis and DNA integrity and may be exploited for use in anticancer therapy.
基金：
NIH grants R01ES017328 (Y.L.)
and R03CA167727 (W.C.), and a grant (DE-FG02-09ER64783) from Low Dose
Radiation Program, U.S. Department of Energy (Y.L).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|2 区生物
小类|2 区生化与分子生物学2 区细胞生物学
最新[2023]版：
大类|1 区生物学
小类|1 区生化与分子生物学2 区细胞生物学
第一作者：
第一作者机构：[1]Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, USA
通讯作者：
通讯机构：[1]Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, USA[*1]Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA.
推荐引用方式(GB/T 7714)：
Chen W,Wang Q,Bai L,et al.RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis.[J].Cell death and differentiation.2014,21(7):1061-70.doi:10.1038/cdd.2014.25.
APA：
Chen W,Wang Q,Bai L,Chen W,Wang X...&Lin Y.(2014).RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis..Cell death and differentiation,21,(7)
MLA：
Chen W,et al."RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis.".Cell death and differentiation 21..7(2014):1061-70
生物学