机构：[1]Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan[2]Department of Radiation Oncology, Sichuan Tumor Hospital, Chengdu 610041, P.R. China四川省肿瘤医院[3]Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a key component of the non-homologous end-joining (NHEJ) pathway, is involved in DNA double-strand break repair, immunocompetence, genomic integrity, and epidermal growth factor receptor signaling. Clinical studies indicate that expression and activity of DNA-PKcs is correlated with cancer progression and response to treatment. Various anti-DNA-PKcs strategies have been developed and tested in preclinical studies to exploit the benefit of DNA-PKcs inhibition in sensitization of radiotherapy and in combined modality therapy with other antitumor agents. In this article, we review the association between DNA-PKcs and cancer development and discuss current approaches and mechanisms for inhibition of DNA-PKcs. The future challenges are to understand how DNA-PKcs activity is correlated with cancer susceptibility and to identify those patients who would most benefit from DNA-PKcs inhibition.
基金：
National Aeronautics and Space Administration (NNX07AP84G), National Institutes
of Health (CA166677), and the Cancer Prevention Research Institute of Texas (RP110465).
第一作者机构：[1]Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
通讯作者：
通讯机构：[3]Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA[*1]Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 2201 Inwood Rd., Rm. NC7.502, Dallas, TX 75390-9187, USA.
推荐引用方式(GB/T 7714)：
Hsu Feng-Ming,Zhang Shichuan,Chen Benjamin P. C..Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment[J].TRANSLATIONAL CANCER RESEARCH.2012,1(1):22-34.doi:10.3978/j.issn.2218-676X.2012.04.01.
APA：
Hsu, Feng-Ming,Zhang, Shichuan&Chen, Benjamin P. C..(2012).Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment.TRANSLATIONAL CANCER RESEARCH,1,(1)
MLA：
Hsu, Feng-Ming,et al."Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment".TRANSLATIONAL CANCER RESEARCH 1..1(2012):22-34
