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Oral lesions, chronic diseases and the risk of head and neck cancer.

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机构: [a]Division of Public Health, Department of Family and Preventive Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA [b]Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA [c]Genomics Research Center, Academia Sinica, Taipei, Taiwan [d]Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan [e]Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan [f]Department of Epidemiology and Biostatistics, West China Center of Medical Sciences, Sichuan University, Chengdu, China [g]Department of Oral Surgery, West China Hospital of Stomatology, Sichuan University, Sichuan, China [h]Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, China [i]Department of Epidemiology and Biostatistics, School of Public Health, Fujian Medical University, Fujian, China [j]Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China [k]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China [l]Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China [m]Department of Epidemiology, School of Public Health, China Medical University, Liaoning, China [n]Department of Head & Neck Oncology, Henan Cancer Hospital, Henan, China [o]Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA [p]Department of Epidemiology and Center for Environmental Genomics, UCLA Fielding School of Public Health, Los Angeles, CA, USA [q]National Office of Cancer Prevention & Control Cancer Institute & Hospital, and Chinese Academy of Medical Sciences, Beijing, China
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关键词: Head and neck cancer Diabetes Oral precancer Depression

摘要:
The aim of our study is to explore the role of the history of oral lesions and chronic diseases on the risk of head and neck cancer in a Chinese population. Our case-control study included 921 head and neck cancer cases and 806 controls. We obtained medical history information by administering questionnaires to both cases and controls. We used unconditional logistic regression to estimate odds ratios for oral lesions and chronic conditions. Oral submucous fibrosis (OR=24.24, 95% CI=7.39-79.52), oral leukoplakia (OR=4.05, 95% CI=2.44-6.71) and repetitive dental ulcers (OR=5.12, 95% CI=3.17-8.28) increased the risk of HNC. Depression was associated with HNC risk when adjusted for several covariates (OR=2.10, 95% CI=1.06-4.15), but the association was not statistically significant after adjusting for smoking and alcohol drinking (OR=1.53, 95% CI=0.72-3.25). Also, the crude OR suggested an association between diabetes and HNC risk (OR=1.51, 95% CI=1.09-2.11), but it was not significant after adjusting for confounders. Our study reported on strong associations between HNC risk and oral leukoplakia, oral submucous fibrosis, which is consistent with prior research. We also observed repetitive dental ulcer to be associated with HNC risk. Future studies may focus on studying the association between depression and HNC, using medical records or psychological evaluation results to get more accurate information about depression, with careful assessment of tobacco and alcohol history. Copyright © 2015 Elsevier Ltd. All rights reserved.

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出版当年[2015]版:
大类 | 3 区 医学
小类 | 2 区 牙科与口腔外科 3 区 肿瘤学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 牙科与口腔外科 3 区 肿瘤学
第一作者:
第一作者机构: [a]Division of Public Health, Department of Family and Preventive Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA
通讯作者:
通讯机构: [a]Division of Public Health, Department of Family and Preventive Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA [*1]Division of Public Health, Department of Family & Preventive Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA.
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