LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy
研究单位：[1]Boehringer Ingelheim[2]Beijing Chao-Yang Hospital,Beijing,China,100020[3]Cancer Hospital of Chinese Academy of Medical Science,Beijing,China,100021[4]Navy General Hospital,Beijing,China,100037[5]Peking Union Medical College Hospital,Beijing,China,100730[6]The First Affiliated Hospital Of Bengbu Medical College,Bengbu,China,233004[7]The First Hospital of Jilin University,Changchun,China,130021[8]Sichuan Cancer Hospital,Chengdu,China,610041[9]West China Hospital,Chengdu,China,610042[10]Sun Yat-Sen University Cancer Center,Guangzhou,China,510060[11]The Third Affiliated Hospital of Harbin Medical University,Haerbin,China,150081[12]Zhejiang Cancer Hospital,Hangzhou,China,310022[13]the 81th Hospital of PLA,Nanjing,China,210002[14]Renji Hospital Shanghai Jiaotong Univesrity School of Medicine,Shanghai,China,200001[15]Shanghai Changzheng Hospital,Shanghai,China,200003[16]Shanghai Ninth People's Hospital,Shanghai,China,200011[17]Fudan University Shanghai Cancer Center,Shanghai,China,200032[18]Shanghai Ninth People's Hospital,Shanghai,China,200125[19]Wuhan Union Hospital,Wuhan,China,430022[20]Tongji Hospital, Tongji University,Wuhan,China,430030[21]Alexandria Clinical Research Center,Alexandria,Egypt,21131[22]National Cancer Institute, Cairo University,Cairo,Egypt,11796[23]Mansoura University Faculty of Medicine,Dakahlia,Egypt,35516[24]Pamela Youde Nethersole Eastern Hospital,Hong Kong,Hong Kong,999077[25]Queen Mary Hospital,Hongkong,Hong Kong,999077[26]Prince of Wales Hospital,Shatin,Hong Kong,999077[27]Sujan Surgical Cancer Hospital,Amravati,India,444606[28]Pristine Hospital,Bengaluru,India,560086[29]Acharya Tulsi Regional Cancer Treatment & Research Institute,Bikaner,India,334001[30]Rajiv Gandhi Government General Hospital,Chennai,India,600003[31]M N J Institute of Oncology and Regional Cancer Centre,Hyderabad,India,500004[32]Geetanjali Medical College and Hospital,Jaipur,India,313002[33]J K Cancer Institute,Kanpur,India,208005[34]B. P .Poddar Hospital & Medical Research Ltd.,Kolkata, West Bengal,India,700053[35]King George Medical University,Lucknow,India,226003[36]Government Medical College & Hospital,Nagpur,India,440009[37]Shatabdi Hospital, Nashik,Nasik,India,422002[38]Ruby Hall Clinic,Pune,India,411001[39]Noble Hospital Pvt Ltd,Pune,India,411013[40]National Cancer Center,Goyang,Korea, Republic of,10408[41]Severance Hospital,Seoul,Korea, Republic of,120-752[42]Samsung Medical Center,Seoul,Korea, Republic of,135-710[43]The Catholic University of Korea, Seoul St.Mary's Hospital,Seoul,Korea, Republic of,137-701[44]Asan Medical Center,Seoul,Korea, Republic of,138-736[45]Perpetual Succour Hospital (Cebu),Cebu City,Philippines,6000[46]St. Luke's Medical Center,Quezon City,Philippines,1102[47]Keelung Chang Gung Memorial Lover's Lake Branch,Keelung City,Taiwan,204[48]Taichung Veterans General Hospital,Taichung,Taiwan,407[49]National Taiwan University Hospital,Taipei,Taiwan,100[50]Tri-Service General Hospital,Taipei,Taiwan,11490[51]Maharaj Nakom Chiangmai Hospital,Chiang Mai,Thailand,50200[52]Srinagarind Hospital,Muang,Thailand,40002[53]Naresuan University Hospital,Phitsanulok,Thailand,65000[54]Songklanagarind Hospital,Songkla,Thailand,90110
研究目的：
This randomized, open-label, phase III study will be performed in patients with recurrent and/or metastatic head and neck cancer which has progressed after platinum-based therapy. The objectives of this trial are to compare the efficacy and safety of afatinib versus methotrexate.
