Immunohistochemical expression of Notch1, Jagged1, NF-κB and MMP-9 in colorectal cancer patients and the relationship to clinicopathological parameters.
机构：[1]Department of Coloproctology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China[2]Department of Gastrointestinal Surgery, Institute of Hepatobiliary, Pancreas and Intestinal Disease, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China[3]Department of Coloproctology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang, China
Activation of Notch and NF-κB signaling has been frequently observed in colorectal cancer (CRC) patients and contributes to the chemo-resistance and treatment failure. However, the relationship between these signaling pathways and CRC has not been clearly described.
To investigate the expression of Notch1, Jagged1, NF-κB and MMP-9 in CRC patients and analyze their correlation with clinicopathological factors.
Expression of Notch1, Jagged1, NF-κB and MMP-9 was visualized by immune-histology in the tumor tissue, adjacent and distant normal tissues from 47 CRC patients without receiving chemotherapy or radiotherapy.
Notch1 (80.8%), Jagged1 (80.8%), NF-κB (70.2%) and MMP-9 (76.6%) were overexpressed in cancer tissues compared normal tissues (P< 0.05). The intensity of Notch1, Jagged1 and NF-κB expression was associated with histological grading, depth of invasion, TNM staging and lymph node metastasis of CRC. MMP-9 was intimately correlated with depth of invasion, TNM staging and lymph node metastasis. NF-κB, MMP-9 and Notch1 expression was positively correlated (P< 0.05), and the same positive correlation was found among NF-κB, MMP-9 and Jagged1 expression (P< 0.05).
Notch1, Jagged1, NF-κB and MMP-9 probably play a pivotal role during the CRC development, serving as biomarkers for early detection of the recurrence and metastasis and prognosis of CRC.
基金：
the Project of Pharmaceutical
Administration (2012ZQ019) and the Project
of Wenzhou Municipal Science and Technology Bureau
(20140009)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Coloproctology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
通讯作者：
通讯机构：[1]Department of Coloproctology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China[*1]Department of Coloproctology, The Second Affiliated Hospital ofWenzhou Medical University, Wenzhou, Zhejiang 325000, China
推荐引用方式(GB/T 7714)：
Zheng Chen-Guo,Chen Rong,Xie Jie-Bin,et al.Immunohistochemical expression of Notch1, Jagged1, NF-κB and MMP-9 in colorectal cancer patients and the relationship to clinicopathological parameters.[J].Cancer biomarkers : section A of Disease markers.2015,15(6):889-97.doi:10.3233/CBM-150533.
APA：
Zheng Chen-Guo,Chen Rong,Xie Jie-Bin,Liu Chang-Bao,Jin Zhao&Jin Chun.(2015).Immunohistochemical expression of Notch1, Jagged1, NF-κB and MMP-9 in colorectal cancer patients and the relationship to clinicopathological parameters..Cancer biomarkers : section A of Disease markers,15,(6)
MLA：
Zheng Chen-Guo,et al."Immunohistochemical expression of Notch1, Jagged1, NF-κB and MMP-9 in colorectal cancer patients and the relationship to clinicopathological parameters.".Cancer biomarkers : section A of Disease markers 15..6(2015):889-97
