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Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond.

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资源类型：
Pubmed体系：
作者：
Lu Guangwen[1,2] * ; Wang Qihui[1,3] ; Gao George F[1,4] ;
机构： [1]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, China [3]CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China [4]Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China
出处：
DOI： 10.1016/j.tim.2015.06.003
ISSN：

关键词： coronavirus interspecies transmission viral and host determinants spike (S) SARS-CoV MERS-CoV

摘要：
Both severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are zoonotic pathogens that crossed the species barriers to infect humans. The mechanism of viral interspecies transmission is an important scientific question to be addressed. These coronaviruses contain a surface-located spike (S) protein that initiates infection by mediating receptor-recognition and membrane fusion and is therefore a key factor in host specificity. In addition, the S protein needs to be cleaved by host proteases before executing fusion, making these proteases a second determinant of coronavirus interspecies infection. Here, we summarize the progress made in the past decade in understanding the cross-species transmission of SARS-CoV and MERS-CoV by focusing on the features of the S protein, its receptor-binding characteristics, and the cleavage process involved in priming. Copyright © 2015 Elsevier Ltd. All rights reserved.

基金：
Work on coronavirus in the laboratory of G.F.G. is supported by the National Natural Science Foundation of China (NSFC, grant numbers 81461168030 and 31400154) and the China National Grand S&T Special Project (number 2014ZX10004-001-006). G.F.G. is a leading principal investigator of the NSFC Innovative Research Group (grant number 81321063). G.L. is supported by the Excellent Young Scientist Grant from the Chinese Academy of Sciences.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类 | 1 区 生物
小类 | 2 区 生化与分子生物学 2 区 微生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 微生物学
第一作者：
第一作者机构： [1]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, China
通讯作者：
通讯机构： [1]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, China [4]Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China
推荐引用方式(GB/T 7714)：
Lu Guangwen,Wang Qihui,Gao George F.Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond.[J].Trends in microbiology.2015,23(8):468-78.doi:10.1016/j.tim.2015.06.003.
APA：
Lu Guangwen,Wang Qihui&Gao George F.(2015).Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond..Trends in microbiology,23,(8)
MLA：
Lu Guangwen,et al."Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond.".Trends in microbiology 23..8(2015):468-78

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