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High salt primes a specific activation state of macrophages, M(Na)(Open Access)

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

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机构： [1]Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai 200031, China [2]Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China [3]Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China [4]Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun YatSen University, Guangzhou, Guangdong 510080, China [5]Cancer Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China [6]Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, Zhejiang 310058, China [7]State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China [8]Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China [9]Laboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China [10]Department of Pathology, University Medical Center of Princeton, Plainsboro, NJ 08854, USA [11]Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA [12]Department of Pathology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA [13]Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA

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关键词： acute lung injury high salt macrophage activation

摘要：

High salt is positively associated with the risk of many diseases. However, little is known about the mechanisms. Here we showed that high salt increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human and mouse macrophages. High salt also potentiated lipopolysaccharide-induced macrophage activation and suppressed interleukin 4-induced macrophage activation. High salt induced the proinflammatory aspects by activating p38/cFos and/or Erk1/2/cFos pathways, while inhibited the anti-inflammatory and proendocytic aspects by Erk1/2/signal transducer and activator of transcription 6 pathway. Consistent with the in vitro results, high-salt diet increased proinflammatory gene expression of mouse alveolar macrophages. In mouse models of acute lung injury, high-salt diet aggravated lipopolysaccharide-induced pulmonary macrophage activation and inflammation in lungs. These results identify a novel macrophage activation state, M(Na), and high salt as a potential environmental risk factor for lung inflammation through the induction of M(Na). © 2015 IBCB, SIBS, CAS.

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出版当年[2015]版：

大类 | 1 区

生物

小类 | 2 区细胞生物学

最新[2023]版：

大类 | 1 区

生物学

小类 | 1 区细胞生物学

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出版当年[2015]版：

Q1 CELL BIOLOGY

最新[2023]版：

Q1 CELL BIOLOGY

影响因子： 28.2 最新[2023版] 36.5 最新五年平均 14.812 出版当年[2015版] 12.393 出版当年五年平均 12.413 出版前一年[2014版] 15.606 出版后一年[2016版]

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第一作者机构： [1]Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai 200031, China

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High salt primes a specific activation state of macrophages, M(Na)(Open Access)

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