机构：[1]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China[2]College of Chemistry, Sichuan University, Chengdu, China
Somatostatin receptors are overexpressed in neuroendocrine tumors, whose endogenous ligands are somatostatin. DOTA-TATE is an analogue of somatostatin, which shows high binding affinity to somatostatin receptors. We aim to evaluate the 68Ga/177Lu-labeling DOTA-TATE kit in neuroendocrine tumor model for molecular imaging and to try human-positron emission tomography/computed tomography imaging of 68Ga-DOTA-TATE in neuroendocrine tumor patients. DOTA-TATE kits were formulated and radiolabeled with 68Ga/177Lu for 68Ga/177Lu-DOTA-TATE (M-DOTA-TATE). In vitro and in vivo stability of 177Lu-DOTA-TATE were performed. Nude mice bearing human tumors were injected with 68Ga-DOTA-TATE or 177Lu-DOTA-TATE for micro-positron emission tomography and micro-single-photon emission computed tomography/computed tomography imaging separately, and clinical positron emission tomography/computed tomography images of 68Ga-DOTA-TATE were obtained at 1 h post-intravenous injection from patients with neuroendocrine tumors. Micro-positron emission tomography and micro-single-photon emission computed tomography/computed tomography imaging of 68Ga-DOTA-TATE and 177Lu-DOTA-TATE both showed clear tumor uptake which could be blocked by excess DOTA-TATE. In addition, 68Ga-DOTA-TATE-positron emission tomography/computed tomography imaging in neuroendocrine tumor patients could show primary and metastatic lesions. 68Ga-DOTA-TATE and 177Lu-DOTA-TATE could accumulate in tumors in animal models, paving the way for better clinical peptide receptor radionuclide therapy for neuroendocrine tumor patients in Asian population.
基金：
Major State Research Development
Program of China (2016YFC0100400), National Natural Science
Foundation of China (No. 81371592, No. 81401467, No.
81501519, and No. 81571705), Beijing Natural Science
Foundation (No. 7154188 and No. 7162041), and Beijing
Municipal Commission of Health and Family Planning (215
backbone program). Scientific Research Foundation for Returned
Scholars of Beijing Municipal Human Resources and Social
Security Bureau (2016) and 2017 Beijing Nova Program also
supported this study.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|3 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China[*1]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
推荐引用方式(GB/T 7714)：
Liu Fei,Zhu Hua,Yu Jiangyuan,et al.68Ga/177Lu-labeled DOTA-TATE shows similar imaging and biodistribution in neuroendocrine tumor model.[J].Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.2017,39(6):1010428317705519.doi:10.1177/1010428317705519.
APA：
Liu Fei,Zhu Hua,Yu Jiangyuan,Han Xuedi,Xie Qinghua...&Yang Zhi.(2017).68Ga/177Lu-labeled DOTA-TATE shows similar imaging and biodistribution in neuroendocrine tumor model..Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,39,(6)
MLA：
Liu Fei,et al."68Ga/177Lu-labeled DOTA-TATE shows similar imaging and biodistribution in neuroendocrine tumor model.".Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 39..6(2017):1010428317705519
