Surgery management for sporadic small (<= 12 cm), non-functioning pancreatic neuroendocrine tumors: A consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET)
机构：[1]Department of General Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai[2]Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University,Guangzhou, Guangdong外科科室胃肠外科中山大学附属第一医院[3]Department of Hepatopancreatobiliary Surgery, Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,Guangdong[4]Department of Gastroenterology,Nanfang Hospial, Southern Medical University,Guangzhou, Guangdong[5]Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai[6]Department of General Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong外科科室普通外科广东省人民医院[7]Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou,Fujian[8]Department of Radiology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing[9]Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center[10]Department of Hepatobiliary and Pancreatic Surgery, West China Hospital, Sichuan University,Chengdu, Sichuan[11]Department of Radiology, Peking University Cancer Hospital and Institute, Beijing[12]Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing[13]Department of Pathology, China-Japan Friendship Hospital, Beijing[14]Department of Radiology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai[15]Department of General Surgery, Rui Jin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai[16]Department of Pathology, Shanghai Cancer Center, Fudan University,Shanghai[17]Department of Pancreatic Surgery, Shanghai Changhai Hospital, Second Military Medical University, Shanghai[18]Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing[19]Department of Gastroenterology, Jiangsu People's Hospital, Nanjing Medical University,Nanjing, Jiangsu内科系统消化内科江苏省人民医院[20]Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Yunnan Research Center for Liver Diseases, Kunming, Yunnan[21]Department of General Surgery, Peking University First Hospital,Beijing[22]Department of Biliary and Pancreatic Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai[23]Department of General Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou,Guangdong[24]Department of General Surgery, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai[25]Department of Gastric and Pancreatic Surgery,Sun Yat-sen University Cancer Center, Guangzhou, Guangdong[26]Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi[27]Department of Surgery, Huzhou Central Hospital, Huzhou, Zhejiang[28]Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai[29]Department of Biliary and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong外科科室胃肠外科中心胃肠外科三科（胃肠胰腺外科）中山大学附属第一医院[30]Department of General Surgery, Peking University Third Hospital, Peking University, Beijing[31]Department of Oncology,Xiangya hospital, Central South University, Changsha, Hunan[32]Department of General Surgery, China-Japan Friendship Hospital, Beijing[33]Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou,Zhejiang[34]Department of Nuclear Medicine, Peiking Union Medical College Hospital, Beijing, P.R. China
The incidence of small (<= 2 cm), non-functioning pancreatic neuroendocrine tumors (NF-pNETs) increased in the last decades. Before making appropriate strategy for patients with NF-pNETs <= 2 cm, pathological confirmation is vital. Incidentally diagnosed, sporadic small NF-pNETs may bring aggressive behavior and poor prognosis, such as extrapancreatic extension, lymph nodal metastasis, distant metastasis and recurrence, even causing disease-related death. Understanding and formulating an appropriate strategy for the patients with sporadic small, non-functioning pancreatic neuroendocrine tumors have been controversial for some time. Although several studies have reported that patients with NF-pNETs <= 2 cm had less rate of malignant behavior compared with larger ones (>2 cm); and the surgery approach may leading to surgery-related pancreatic complications; but there is still a lack of level I evidence to convince surgeons to abandon all cases with sporadic small NF-pNETs. Based on an updated literature search and review, the members of the Chinese Study Group for Neuroendocrine Tumors (CSNET) from high-volume centers have reached a consensus on the issue of the management strategy for the sporadic small NF-pNETs. We recommend that, except for some selected patients with NF-pNETs <1 cm, incidentally discovered and unacceptable surgical risks, all others with NF-pNETs <= 2 cm should undergo tumor resection with lymph node dissection or at least lymph node sampling and careful postoperative surveillance.
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出版当年[2017]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
大类|3 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Department of General Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai
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通讯作者：
通讯机构：[1]Department of General Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai[*1]Department of General Surgery, Shanghai Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, P.R. China
推荐引用方式(GB/T 7714)：
Guang Yang,Meng Ji,Jie Chen,et al.Surgery management for sporadic small (<= 12 cm), non-functioning pancreatic neuroendocrine tumors: A consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET)[J].INTERNATIONAL JOURNAL OF ONCOLOGY.2017,50(2):567-574.doi:10.3892/ijo.2016.3826.
APA：
Guang Yang,Meng Ji,Jie Chen,Rufu Chen,Ye Chen...&Chenghao Shao.(2017).Surgery management for sporadic small (<= 12 cm), non-functioning pancreatic neuroendocrine tumors: A consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET).INTERNATIONAL JOURNAL OF ONCOLOGY,50,(2)
MLA：
Guang Yang,et al."Surgery management for sporadic small (<= 12 cm), non-functioning pancreatic neuroendocrine tumors: A consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET)".INTERNATIONAL JOURNAL OF ONCOLOGY 50..2(2017):567-574
