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Photo-excitable hybrid nanocomposites for image-guided photo/TRAIL synergistic cancer therapy.

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Pubmed体系：

收录情况： ◇ EI

作者：
Lin Gan[1,2] ; Zhang Yang[1] ; Zhu Congqing[3] ; Chu Chengchao[1] ; Shi Yesi[1] ; Pang Xin[1] ; Ren En[1] ; Wu Yayun[1] ; Mi Peng[4] ; Xia Haiping[3] ; Chen Xiaoyuan[5] ; Liu Gang[2] ;
机构： [1]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China [2]Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia [3]State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China [4]Department of Radiology, Center for Medical Imaging, State Key Laboratory of Biotherapy and Cancer Center,West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China [5]Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
出处：
DOI： 10.1016/j.biomaterials.2018.05.036
ISSN：

关键词： TRAIL Photothermal therapy Death receptor Resistance Tumor microenvironment

摘要：
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in cancer cells without toxicity to normal cells. However, the efficiency is greatly limited by its short half-life and wild resistance in various cancer cells. In this study, we reported a micellar hybrid nanoparticle to carry TRAIL ligand (denoted as IPN@TRAIL) for a novel photo-excited TRAIL therapy. These IPN@TRAIL offered increased TRAIL stability, prolonged half-life and enhanced tumor accumulation, monitored by dual mode imaging. Furthermore, IPN@TRAIL nanocomposites enhanced wrapped TRAIL therapeutic efficiency greatly towards resistant cancer cells by TRAIL nanovectorization. More importantly, when upon external laser, these nanocomposites not only triggered tumor photothermal therapy (PTT), but also upregulated the expression of death receptors (DR4 and DR5), resulting in a greater apoptosis mediated by co-delivered TRAIL ligand. Such photo/TRAIL synergistic effect showed its great killing effects in a controllable manner on TRAIL-resistant A549 tumor model bearing mice. Finally, these nanocomposites exhibited rapid clearance without obvious systemic toxicity. All these features rendered our nanocomposites a promising theranostic platform in cancer therapy. Copyright © 2018 Elsevier Ltd. All rights reserved.

基金：
the Major State Basic Research Development Program of China (Grant Nos. 2017YFA0205201, 2013CB733802, and 2014CB744503), the National Natural Science Foundation of China (NSFC) (Grant Nos. 81422023, 81371596, 51273165, U1705281, and U1505221), the Fundamental Research Funds for the Central Universities (Grant Nos. 20720160065 and 20720150141), and the Program for New Century Excellent Talents in University, China (NCET-13-0502).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 1 区 工程技术
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
第一作者：
第一作者机构： [1]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China [2]Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Lin Gan,Zhang Yang,Zhu Congqing,et al.Photo-excitable hybrid nanocomposites for image-guided photo/TRAIL synergistic cancer therapy.[J].Biomaterials.2018,176:60-70.doi:10.1016/j.biomaterials.2018.05.036.
APA：
Lin Gan,Zhang Yang,Zhu Congqing,Chu Chengchao,Shi Yesi...&Liu Gang.(2018).Photo-excitable hybrid nanocomposites for image-guided photo/TRAIL synergistic cancer therapy..Biomaterials,176,
MLA：
Lin Gan,et al."Photo-excitable hybrid nanocomposites for image-guided photo/TRAIL synergistic cancer therapy.".Biomaterials 176.(2018):60-70

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