Apatinib is effective as third-line and more treatment of advanced metastatic non-small-cell lung cancer: A retrospective analysis in a real-world setting.
机构:[1]Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing,[2]Central Hospital of Suining, Department of Oncology, Suining City, Sichuan Province, China
No standard methods are recommended for patients with advanced metastatic non-small-cell lung cancer (NSCLC) experiencing progression after 2 or more lines treatment now. The aim of this retrospective study was to assess the efficacy and safety of apatinib in metastatic NSCLC patients after second-line or more treatments failure in a real-world setting.A total of 52 advanced NSCLC patients who experienced progression after second-line and more treatments and received apatinib from March 2016 to February 2018 were retrospectively reviewed. Patients were treated with oral apatinib 500 mg QD (take the medicine once a day), every 4 weeks for a cycle. Responding and stable patients continued the treatment until progression or intolerable toxicity. The overall survival (OS), progression-free survival (PFS), objective remission rate (ORR) and disease control rate (DCR), and side effects of the drug were collected and reviewed.The ORR and the DCR were 6.9% and 67.4%. The median PFS and median OS of all patients were 3.8 months and 5.8 months, respectively. The Eastern Cooperative Oncology Group score was the independent influencing factor of PFS and OS for the advanced NSCLC patients who were treated with apatinib after second-line and above standard regimens (PFS: hazard ratio [HR] = 4.446, 95% confidence interval [CI]: 1.185-16.678, P = .027 and OS: HR = 8.149, 95% CI: 1.173-56.596, P = .034). The most common adverse events apatinib-related included hypertension (19.2%), hand-foot syndrome (11.5%), and mucous membrane reaction (17.3%). And treatment-related grade 3/4 toxicities were low.Apatinib showed favorable efficacy and safety and could be a treatment option in patients with advanced NSCLC experiencing progression after second-line and more treatment.
基金:
This study was supported by a grant from Natural Science Foundation of
Chongqing municipal science and technology commission, China
(2013jcyjA10125); and a foundation of Young and Middle-age High-level Medical
Reserved Personnel Training of Chongqing, China. All the funding source had no
involvement in the study.
语种:
外文
PubmedID:
中科院(CAS)分区:
出版当年[2019]版:
大类|4 区医学
小类|3 区医学:内科
最新[2023]版:
大类|4 区医学
小类|4 区医学:内科
第一作者:
第一作者机构:[1]Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing,[2]Central Hospital of Suining, Department of Oncology, Suining City, Sichuan Province, China
通讯作者:
通讯机构:[1]Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing,[*1]Department of Medical Oncology, Chongqing University Cancer Hospital, 181 Hanyu Road, Shapingba District, Chongqing 400030, China
推荐引用方式(GB/T 7714):
Leng Jiao,Li Dai-Rong,Huang Lu-Mi,et al.Apatinib is effective as third-line and more treatment of advanced metastatic non-small-cell lung cancer: A retrospective analysis in a real-world setting.[J].Medicine.2019,98(36):e16967.doi:10.1097/MD.0000000000016967.
APA:
Leng Jiao,Li Dai-Rong,Huang Lu-Mi,Ji Xiao-Hui&Wang Dong-Lin.(2019).Apatinib is effective as third-line and more treatment of advanced metastatic non-small-cell lung cancer: A retrospective analysis in a real-world setting..Medicine,98,(36)
MLA:
Leng Jiao,et al."Apatinib is effective as third-line and more treatment of advanced metastatic non-small-cell lung cancer: A retrospective analysis in a real-world setting.".Medicine 98..36(2019):e16967