研究单位：[1]Hoffmann-La Roche[2]University of California San Diego,La Jolla,California,United States,92093[3]UC Davis[4]Comprehensive Cancer Center,Sacramento,California,United States,95817[5]Rocky Mountain Cancer Center,Denver,Colorado,United States,80218[6]Eastern Connecticut Hematology and Oncology Associates[7](ECHO),Norwich,Connecticut,United States,06360[8]SCRI Florida Cancer Specialists South,Fort Myers,Florida,United States,33916[9]Florida Cancer Specialist, North Region,Saint Petersburg,Florida,United States,33705[10]University Cancer & Blood Center, LLC[11]Research,Athens,Georgia,United States,30607[12]Illinois Cancer Care,Peoria,Illinois,United States,61615[13]University of Kentucky[14]Markey Cancer Center,Lexington,Kentucky,United States,40536[15]University of Michigan Comprehensive Cancer Center,Ann Arbor,Michigan,United States,48109[16]Henry Ford Health System[17]Hematology/Oncology,Detroit,Michigan,United States,48202-2689[18]Comprehensive Cancer Centers of Nevada,Las Vegas,Nevada,United States,89128[19]Dartmouth Hitchcock Medical Center,Lebanon,New Hampshire,United States,03756[20]Cancer Inst. Of New Jersey,New Brunswick,New Jersey,United States,08901[21]Montefiore Medical Center,Bronx,New York,United States,10461[22]Weill Cornell Medical College-New York Presbyterian Hospital,New York,New York,United States,10021[23]Ohio State University,Columbus,Ohio,United States,43212-3153[24]Oregon HSU,Portland,Oregon,United States,97210[25]St. Luke's University Health network,Bethlehem,Pennsylvania,United States,18015[26]SCRI Tennessee Oncology Chattanooga,Chattanooga,Tennessee,United States,37404[27]Tennessee Oncology PLLC - Nashville (20th Ave),Nashville,Tennessee,United States,37203[28]Texas Oncology - South Austin,Austin,Texas,United States,78745[29]Oncology Consultants PA,Houston,Texas,United States,77030[30]Virginia Cancer Specialists, PC,Fairfax,Virginia,United States,22031[31]University of Washington Seattle Cancer Care Alliance,Seattle,Washington,United States,98195[32]Fundación CENIT para la Investigación en Neurociencias,Buenos Aires,Argentina,C1125ABD[33]Hospital Italiano,Buenos Aires,Argentina,C1181ACH[34]Hospital Britanico de Buenos Aires,Ciudad Autonoma Buenos Aires,Argentina,C1284AEB[35]Centro Oncologico Riojano Integral (CORI),La Rioja,Argentina,F5300COE[36]Royal North Shore Hospital[37]Department of Medical Oncology,St Leonards,New South Wales,Australia,2065[38]The Prince Charles Hospital[39]Oncology Dept.,Chermside,Queensland,Australia,4032[40]Ashford Cancer Center Research,Kurralta Park,South Australia,Australia,5037[41]Austin Hospital[42]Medical Oncology,Heidelberg,Victoria,Australia,3084[43]Sir Charles Gairdner Hospital,Nedlands,Western Australia,Australia,6009[44]UZ Brussel,Brussel,Belgium,1090[45]Cliniques Universitaires St-Luc,Bruxelles,Belgium,1200[46]UZ Leuven Gasthuisberg,Leuven,Belgium,3000[47]Instituto Nacional de Cancer - INCa[48]Oncologia,Rio de Janeiro,RJ,Brazil,20560-120[49]Hospital de Caridade de Ijui[50]Oncologia,Ijui,RS,Brazil,98700-000[51]Hospital Sao Lucas - PUCRS,Porto Alegre,RS,Brazil,90610-000[52]Instituto do Cancer do Estado de Sao Paulo - ICESP,Sao Paulo,SP,Brazil,01246-000[53]Cross Cancer Institute,Edmonton,Alberta,Canada,T6G 1Z2[54]CancerCare Manitoba[55]Department of Medical Oncology,Winnipeg,Manitoba,Canada,R3E 0V9[56]Royal Victoria Regional Health Centre[57]c/o Oncology Clinical Trials,Barrie,Ontario,Canada,L4M 6M2[58]William Osler Health System Brampton Civic Hospital,Brampton,Ontario,Canada,L6R 3J7[59]London Health Sciences Centre · Victoria Hospital[60]Department of Medicine,London,Ontario,Canada,N6A 5W9[61]Lakeridge Health Center[62]R. S. MacLaughlin Durham Regional Cancer Center,Oshawa,Ontario,Canada,L1G 2B9[63]Sunnybrook Health Sciences Centre,Toronto,Ontario,Canada,M4N 3M5[64]Princess Margaret Cancer Center,Toronto,Ontario,Canada,M5G 1Z5[65]Jewish General Hospital,Montreal,Quebec,Canada,H3T 1E2[66]IUCPQ (Hôpital Laval),Quebec City,Quebec,Canada,G1V 4G5[67]Saskatoon Cancer Centre,Saskatoon,Saskatchewan,Canada,SK S7N 4H4[68]Biocenter,Concepción,Chile[69]Bradford Hill Centro de Investigaciones Clinicas,Recoleta,Chile,8420383[70]Beijing Cancer Hospital,Beijing,China,100142[71]Jilin Cancer Hospital,Changchun,China,132013[72]The second Xiangya hospital of central south university,Changsha City,China,410100[73]Sichuan Cancer Hospital,Chengdu City,China,610041[74]West China Hospital - Sichuan University,Chengdu City,China,610047[75]The First Affiliated Hospital of Guangzhou Medical University Pharmacy,Guangzhou,China,510120[76]Zhejiang Cancer Hospital[77]Zhejiang Cancer Hospital cancer department,Hangzhou City,China,310022[78]Harbin Medical University Cancer Hospital,Harbin,China,150081[79]Shandong Cancer Hospital,Jinan,China,250117[80]The Second Affiliated Hospital to Nanchang University,Nanchang,China,330006[81]Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School,Nanjing City,China,210008[82]Fudan Unviversity Shanghai Cancer Center,Shanghai,China,200032[83]Xiehe Hospital, Tongji Medical College Huazhong University of Science & Technology,Wuhan,China,430022[84]First Affiliated Hospital of Medical College of Xi''an Jiaotong University,Xi''an,China,710061[85]Clinica CIMCA,San José,Costa Rica,10103[86]Institut Bergonie CLCC Bordeaux,Bordeaux,France,33000[87]Centre Francois Baclesse[88]Radiologie,Caen,France,14076[89]Centre Oscar Lambret,Lille,France,59020[90]Centre Léon Bérard,Lyon,France,69373[91]Hopital Caremeau[92]Pneumologie,Nimes,France,30029[93]Hopital Bichat Claude Bernard[94]Oncologie Serv.,Paris,France,75018[95]Hôpital Européen Georges Pompidou,Paris,France,75908[96]Hopital Tenon[97]Pneumologie,Paris,France,75970[98]CHU Poitiers,Poitiers,France,86000[99]Hopital Pontchaillou,Rennes,France,35033[100]CHU de Toulouse - Hôpital Larrey[101]Service de pneumologie et oncologie pneumologique,Toulouse cedex 9,France,31100[102]Hopital Bretonneau[103]Pneumologie Oncologie,Tours,France,37044[104]Hopital Robert Schuman[105]Pneumologie,Vantoux,France,57070[106]Klinikum Chemnitz gGmbH,Chemnitz,Germany,09116[107]Universitätsklinikum Düsseldorf[108]Klinik für Kardiologie, Pneumologie und Angiologie,Düsseldorf,Germany,40225[109]Universitätsklinikum Essen[110]Innere Klinik (Tumorforschung),Essen,Germany,45147[111]Klinikum Esslingen[112]Klinik für Kardiologie, Angiologie und Pneumologie,Esslingen,Germany,73730[113]Asklepios-Fachklinik Muenchen-Gauting[114]Klinik Für Pneumologie,Gauting,Germany,82131[115]Robert Bosch Krankenhaus[116]Pneumologie und pneumologische Onkologie,Gerlingen,Germany,70839[117]Thoraxklinik Heidelberg gGmbH,Heidelberg,Germany,69126[118]HSK Dr.-Horst-Schmidt-Kliniken Klinik für Innere Medizin III Onkologie Hämatologie und Palliativmed,Wiesbaden,Germany,65199[119]Pamela Youde Nethersole Eastern Hospital,Hong Kong,Hong Kong,Chai Wan[120]Queen Mary Hospital[121]Medicine & Respiratory,Hong Kong,Hong Kong[122]Prince of Wales Hosp[123]Dept. Of Clinical Onc,Shatin,Hong Kong[124]Soroka Medical Center[125]Oncology Dept,Beer Sheva,Israel,8410100[126]Rambam Health Care Campus[127]Oncology,Haifa,Israel,3109601[128]Meir Medical Center[129]Oncology,Kfar-Saba,Israel,4428164[130]Rabin MC[131]Davidof Center - Oncology Institute,Petach Tikva,Israel,4941492[132]Chaim Sheba Medical Center[133]Oncology Dept,Ramat Gan,Israel,5262100[134]Sourasky / Ichilov Hospital[135]Dept. of Oncology,Tel Aviv,Israel,6423906[136]Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale,Napoli,Campania,Italy,80131[137]IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola[138]Oncologia Medica,Meldola,Emilia-Romagna,Italy,47014[139]Irccs Centro Di Riferimento Oncologico (CRO),Aviano,Friuli-Venezia Giulia,Italy,33081[140]Azienda Ospedaliera San Camillo Forlanini,Roma,Lazio,Italy,151[141]Asst Papa Giovanni XXIII[142]Oncologia Medica,Bergamo,Lombardia,Italy,24127[143]ASST di Cremona - Azienda Socio Sanitaria Territoriale di Cremona,Cremona,Lombardia,Italy,26100[144]Irccs Istituto Europeo di Oncologia (IEO)[145]Divisione di Oncologia,Milano,Lombardia,Italy,20141[146]Asst Di Monza,Monza,Lombardia,Italy,20900[147]Azienda Sanitaria Ospedaliera S Luigi Gonzaga[148]S.C.D.U. di Oncologia Toracica,Orbassano (TO),Piemonte,Italy,10043[149]Fujita Health University Hospital,Aichi,Japan,470-1192[150]National Cancer Center Hospital East,Chiba,Japan,277-8577[151]Shikoku Cancer Center,Ehime,Japan,791-0280[152]National Hospital Organization Kyushu Medical Center,Fukuoka,Japan,810-8563[153]National Hospital Organization Kyushu Cancer Center,Fukuoka,Japan,811-1395[154]Kyushu University Hospital,Fukuoka,Japan,812-8582[155]Hiroshima University Hospital,Hiroshima,Japan,734-8551[156]Kanazawa University Hospital,Ishikawa,Japan,920-8641[157]Kanagawa Cancer Center,Kanagawa,Japan,241-8515[158]University Hospital Kyoto Prefectural University of Medicine,Kyoto,Japan,602-8566[159]Kyoto University Hospital,Kyoto,Japan,606-8507[160]Sendai Kousei Hospital,Miyagi,Japan,980-0873[161]Tohoku University Hospital,Miyagi,Japan,980-8574[162]Niigata University Medical & Dental Hospital,Niigata,Japan,951-8520[163]Niigata Cancer Center Hospital,Niigata,Japan,951-8566[164]Okayama University Hospital,Okayama,Japan,700-8558[165]Kindai University Hospital,Osaka,Japan,589-8511[166]Saga University Hospital,Saga,Japan,849-8501[167]Shizuoka Cancer Center,Shizuoka,Japan,411-8777[168]Juntendo University Hospital,Tokyo,Japan,113-8431[169]Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital,Tokyo,Japan,113-8677[170]The Cancer Institute Hospital of JFCR,Tokyo,Japan,135-8550[171]Kyorin University Hospital,Tokyo,Japan,181-8611[172]Wakayama Medical University Hospital,Wakayama,Japan,641-8510[173]National Hospital Organization Yamaguchi - Ube Medical Center,Yamaguchi,Japan,755-0241[174]National Cancer Center,Goyang-si,Korea, Republic of,10408[175]Seoul National University Hospital,Seoul,Korea, Republic of,03080[176]Asan Medical Center,Seoul,Korea, Republic of,05505[177]Yonsei University Health System/Severance Hospital,Seoul,Korea, Republic of,120-752[178]Health Pharma Professional Research,Cdmx,Mexico CITY (federal District),Mexico,03100[179]Oncologico Potosino,San Luis Potosí,SAN LUIS Potosi,Mexico,78209[180]AVIX Investigación Clínica S.C,Monterrey,Mexico,64710[181]Hospital Angeles Tijuana,Tijuana,Mexico,22010[182]UMCG,NL -groningen,Netherlands,9700 RB[183]Erasmus MC,Rotterdam,Netherlands,3015 GD[184]Auckland City Hospital,Auckland,New Zealand,1023[185]Hemato Oncología de Panamá Especializada,Panama City,Panama,0801[186]Hospital Nacional Edgardo Rebagliati Martins[187]Oncologia,Lima,Peru,11[188]Instituto Nacional de Enfermedades Neoplasicas,Lima,Peru,Lima 34[189]Clinica Ricardo Palma,San Isidro,Peru,Lima 27[190]Uniwersyteckie Centrum Kliniczne, Klinika Onkologii I Radioterapii,Gdansk,Poland,80-214[191]Krakowski Szpital Specjalistyczny im.Jana Pawla II,Krakow,Poland,31-202[192]Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie[193]Oddzial onkologii z pododdzialem chemioterapii,Olsztyn,Poland,10-357[194]Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy[195]Oddzial Iii,Otwock,Poland,05-400[196]Wielkopolskie Centrum Pulmonologii I Torakochirurgii w Poznaniu,Poznan,Poland,60-569[197]Narod.Inst.Onkol. Im. M.Sklodowskiej - Curie-Panst.Inst.Bad[198]Klinika Nowot.Pluca I Klatki Piers,Warszawa,Poland,02-781[199]Moscow City Oncology Hospital #62,Moscovskaya Oblast,Moskovskaja Oblast,Russian Federation,143423[200]Principal Military Clinical Hospital n.a. N.N. Burdenko,Moscow,Moskovskaja Oblast,Russian Federation,105229[201]FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF,Moscow,Russian Federation,115478[202]Clinical Oncology Dispensary[203]Chemotherapy,Omsk,Russian Federation,644013[204]S-Pb clinical scientific practical center of specialized kinds of medical care (oncological),Saint-Petersburg,Russian Federation,197758[205]Saint-Petersburg City Clinical Oncology Dispensary,St Petersburg,Russian Federation,197022[206]Clinical Center of Serbia,Belgrade,Serbia,11000[207]University Hospital Medical Center Bezanijska kosa,Belgrade,Serbia,11080[208]Clinical Center Nis,NIS,Serbia,18000[209]Institute for Pulmonary Diseases of Vojvodina,Sremska Kamenica,Serbia,21204[210]National University Hospital[211]National University Cancer Institute, Singapore (NCIS),Singapore,Singapore,119228[212]National Cancer Centre[213]Medical Oncology,Singapore,Singapore,168583[214]Insititut Catala D''Oncologia,Hospitalet de Llobregat,Barcelona,Spain,08908[215]Complejo Hospitalario Universitario de Santiago (CHUS)[216]Servicio de Oncologia,Santiago de Compostela,LA Coruña,Spain,15706[217]Hospital Universitario Puerta de Hierro[218]Servicio de Oncologia,Majadahonda,Madrid,Spain,28222[219]Hospital Quiron de Madrid[220]Servicio de Oncologia,Pozuelo de Alarcon,Madrid,Spain,28223[221]Clinica Universitaria de Navarra[222]Servicio de Oncologia,Pamplona,Navarra,Spain,31008[223]Hospital General Univ. de Alicante,Alicante,Spain,03010[224]Hospital Universitari Vall d''Hebron[225]Oncology,Barcelona,Spain,08035[226]Hospital Clínic I Provincial[227]Servicio de Hematología y Oncología,Barcelona,Spain,08036[228]ICO Badalona - Hospital Germans Trias I Pujol,Barcelona,Spain,08916[229]Hospital General Universitario Gregorio Marañon[230]Servicio de Oncologia,Madrid,Spain,28007[231]Hospital Ramon y Cajal[232]Servicio de Oncologia,Madrid,Spain,28034[233]Hospital Universitario 12 de Octubre[234]Servicio de Oncologia,Madrid,Spain,28041[235]Centro Integral Oncologico Clara Campal[236]Servicio de Oncología,Madrid,Spain,28050[237]Hospital Regional Universitario Carlos Haya[238]Servicio de Oncologia,Malaga,Spain,29011[239]Hospital Universitario Virgen del Rocio[240]Servicio de Oncologia,Sevilla,Spain,41013[241]Hospital Clínico Universitario de Valencia[242]Servicio de Oncología,Valencia,Spain,46010[243]Kaohsiung Chang Gung Memorial Hospital[244]Dept of Internal Medicine,Kaohsiung,Taiwan,83301[245]National Taiwan Uni Hospital[246]Internal Medicine,Taipei,Taiwan,100[247]Taipei Medical University Hospital,Taipei,Taiwan,110[248]Taipei Veterans General Hospital[249]Chest Dept , Section of Thoracic Oncology,Taipei,Taiwan,112[250]Chang Gung Medical Foundation - Linkou[251]Chest Dept,Taoyuan,Taiwan,333[252]Chulalongkorn Hospital[253]Medical Oncology,Bangkok,Thailand,10330[254]Ramathibodi Hospital[255]Dept of Med.-Div. of Med. Onc,Bangkok,Thailand,10400[256]Faculty of Med. Siriraj Hosp.[257]Med.-Div. of Med. Oncology,Bangkok,Thailand,10700[258]Prince of Songkla University[259]Division of Pulmonary Disease, Department of Medicine,Hat Yai,Thailand,90110[260]Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital[261]Medical Oncology,Adana,Turkey,01230[262]Akdeniz University Medical Faculty[263]Medical Oncology Department,Antalya,Turkey,07070[264]Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department,Edirne,Turkey,22770[265]Medipol University Medical Faculty[266]Oncology Department,Istanbul,Turkey,34214[267]Marmara University Pendik Training and Research Hospital[268]Medikal Onkoloji,Istanbul,Turkey,34890[269]Medikal Park Izmir Hospital,Kar??yaka,Turkey,35575[270]Hacettepe Uni Medical Faculty Hospital[271]Oncology Dept,Sihhiye/Ankara,Turkey,06230
研究目的：
This is a phase 2/3, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in combination in participants with unresectable, advanced or metastatic NSCLC determined to harbor oncogenic somatic mutations or positive by tumor mutational burden (TMB) assay as identified by two blood-based next-generation sequencing (NGS) circulating tumor DNA (ctDNA) assays.
