机构：[1]Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education , Shihezi University College of Pharmacy , Shihezi 832003 , P. R. China.[2]Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education , Peking University Institute of Cardiovascular Sciences Peking University Health Science Center , 38 Xueyuan Rode , Beijing 100191 , P. R. China.[3]State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, West China Hospital , Sichuan University-Collaborative Innovation Center for Biotherapy , Chengdu 610041 , P. R. China.四川大学华西医院
Ulcerative colitis (UC) has been listed as one of the refractory diseases of modern society by the World Health Organization. Our previous studies found that Turkish galls Gallotannins (TGTs) have a significant effect on anti-UC. Here, TGTs were extracted using a simple method and TGTs-FeIII microcapsules were prepared by a self-assembly technique. Microcapsules were characterized by liquid chromatography-mass spectrometry, scanning electron microscopy, and so forth. The results verified that hollow spheres of TGTs-FeIII microcapsules were successfully prepared. It is interesting that microcapsules were more likely to accumulate on the inflammatory surface from ex vivo and in vivo adhesion experiments, and effectively alleviate UC symptoms. This study will provide valuable insight into the development of safe and efficient drug delivery system platforms for further biomedical usages.
基金：
National
Natural Science Foundation of China (Grant No. 81560699,
81760756), Young and Middle-Aged Scientific and Technological
Innovation Leading Talent Program of the Production
and Construction Corps (Grant No. 2016BC001), Outstanding
Young Scientific Personnel Training Plan of Shihezi
University (Grant No. 2015-ZRKXJQ08), and Achievement
Transformation and Technology Promotion Plan of Shihezi
University (CGZH201806).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|1 区材料科学
小类|2 区纳米科技2 区材料科学：综合
最新[2023]版：
大类|2 区材料科学
小类|2 区材料科学：综合2 区纳米科技
第一作者：
第一作者机构：[1]Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education , Shihezi University College of Pharmacy , Shihezi 832003 , P. R. China.[2]Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education , Peking University Institute of Cardiovascular Sciences Peking University Health Science Center , 38 Xueyuan Rode , Beijing 100191 , P. R. China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Xing,Zang Jie,Ma Shangzhi,et al.Hollow Microcapsules with Ulcerative Colitis Therapeutic Effects Made of Multifunctional Turkish Galls Extraction.[J].ACS applied materials & interfaces.2019,11(28):25054-25065.doi:10.1021/acsami.9b07557.
APA：
Zhang Xing,Zang Jie,Ma Shangzhi,Yu Wei,Long Fei...&Han Bo.(2019).Hollow Microcapsules with Ulcerative Colitis Therapeutic Effects Made of Multifunctional Turkish Galls Extraction..ACS applied materials & interfaces,11,(28)
MLA：
Zhang Xing,et al."Hollow Microcapsules with Ulcerative Colitis Therapeutic Effects Made of Multifunctional Turkish Galls Extraction.".ACS applied materials & interfaces 11..28(2019):25054-25065
材料科学