机构：[1]Department of Gastroenterology and the Center of Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[2]Department of Geriatrics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院[3]Lab of Inflammatory Bowel Disease, Clinical institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院
Background: A meta-analysis was conducted on the incidence of colon cancer in patients with ulcerative colitis (UC). This study aimed to evaluate the correlation between UC and colon cancer, and provide a theoretical guidance for clinical diagnoses and treatments of UC. Methods: Articles were searched in Chinese database with "ulcerative colitis", "UC", "colon cancer", "colorectal cancer", "incidence", and "meta-analysis" as the search terms. Articles were searched in English database with "ulcerative colitis", "UC", "colon cancer", "incidence rate", and "meta-analysis" as the search terms. Moreover, articles with the topic of "correlation between UC and colon cancer" were screened. The quality of articles was assessed using Rev Man 5.3 software provided by Cochrane system. Results: Eleven articles were included, most of which were of medium and high quality. Results of metaanalysis showed that 12,216 patients with UC were included in this study, and 110 patients developed colon cancer. There was statistical heterogeneity (Chi(2)=103.10, I-2=90%, P<0.00001). Random-effect model analyses showed that there were no significant differences between colon cancer in patients with UC and those without colon cancer (Z=12.44, P<0.00001). A systematic review of articles found that the course and development of colon cancer in patients with UC might affect the occurrence of colon cancer. UC was a risk factor for colorectal cancer. Discussion: It was found that the course of disease and the occurrence and development of UC might affect the occurrence of colon cancer through a systematic review of articles. UC was one of the risk factors of colorectal cancer.
基金：
National
Natural Science Foundation of China (No. 81470826),
the Science Foundation from Science & Technology
Department of Sichuan Province (No. 2019YFS0262;
No. 2020YFS0410; No. 22ZDYF1691; No. 2018FZ0062)
and 1.3.5 project for disciplines of excellence, West China
Hospital, Sichuan University (No. ZYGD18023).
第一作者机构：[1]Department of Gastroenterology and the Center of Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China[2]Department of Geriatrics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
通讯作者：
通讯机构：[1]Department of Gastroenterology and the Center of Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China[3]Lab of Inflammatory Bowel Disease, Clinical institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China[*1]The Center of Inflammatory Bowel Disease, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, China.
推荐引用方式(GB/T 7714)：
Zhang Li,Gan Huatian.Secondary colon cancer in patients with ulcerative colitis: a systematic review and meta-analysis[J].JOURNAL OF GASTROINTESTINAL ONCOLOGY.2021,12(6):2882-2890.doi:10.21037/jgo-21-800.
APA：
Zhang, Li&Gan, Huatian.(2021).Secondary colon cancer in patients with ulcerative colitis: a systematic review and meta-analysis.JOURNAL OF GASTROINTESTINAL ONCOLOGY,12,(6)
MLA：
Zhang, Li,et al."Secondary colon cancer in patients with ulcerative colitis: a systematic review and meta-analysis".JOURNAL OF GASTROINTESTINAL ONCOLOGY 12..6(2021):2882-2890
