机构:[1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China四川大学华西医院[2]West China Medical School, Sichuan University, Chengdu, Sichuan, People’s Republic of China四川大学华西医院
Lipid profiles are believed to play an important role in the tumorigenesis and progression of prostate cancer (PCa), but research combining those data is lacking. Therefore, this meta-analysis aims to assess the prognostic role of lipid profiles after RP.
We systematically searched PubMed, Embase, and Cochrane Library Central Register of Controlled Trials for articles evaluating association between lipid profiles and prognosis after RP. Odds ratio (OR) and hazard ratio (HR) of lipid profiles for advanced pathological tumor features and biochemical recurrence (BCR) were extracted and pooled OR and HR were calculated. Newcastle-Ottawa scale was used for study quality assessment and funnel plot was used for evaluating publication bias.
Twelve articles involving 11,108 patients were eventually selected. We found low HDL was associated with more frequent occurrence of pathological T stage (pT) ≥ T3 (pooled OR = 1.29, 95% CI 1.07-1.56) and Gleason score (GS) ≥8 (pooled OR = 1.32, 95% CI 1.02-1.72) after RP. Hypertriglyceridemia was also linked with higher risk of pT ≥ T3 (pooled OR = 1.20, 95% CI 1.01-1.42) and positive surgical margin (PSM) (pooled OR = 1.36, 95% CI 1.11-1.65). However, no significant association was observed between BCR and abnormal lipid profile levels.
Low HDL level was associated with more common occurrence of pT ≥ T3 and GS ≥8, and elevated triglycerides level was linked higher risk of pT ≥ T3 and PSM, but none of the lipid subfractions was correlated with biochemical recurrence after RP.
基金:
National key research and development
program of China (Grant No. SQ2017YFSF090096), the Prostate Cancer Foundation
Young Investigator Award 2013, the National Natural Science Foundation of China
(Grant No. 81300627, 81370855, 81702536, 81770756), Programs from Science and
Technology Department of Sichuan Province (Grant No. 2014JY0219 and
2017HH0063) and Young Investigator Award of Sichuan University 2017
(2017SCU04A17).
语种:
外文
PubmedID:
中科院(CAS)分区:
出版当年[2019]版:
大类|3 区医学
小类|3 区生化与分子生物学4 区营养学
最新[2023]版:
大类|2 区医学
小类|2 区生化与分子生物学3 区营养学
第一作者:
第一作者机构:[1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Zheng Xiaonan,Han Xin,Xu Hang,et al.Prognostic value of lipid profiles after radical prostatectomy: a systematic review and meta-analysis.[J].Lipids in health and disease.2019,18(1):124.doi:10.1186/s12944-019-1068-6.
APA:
Zheng Xiaonan,Han Xin,Xu Hang,Ai Jianzhong,Yang Lu&Wei Qiang.(2019).Prognostic value of lipid profiles after radical prostatectomy: a systematic review and meta-analysis..Lipids in health and disease,18,(1)
MLA:
Zheng Xiaonan,et al."Prognostic value of lipid profiles after radical prostatectomy: a systematic review and meta-analysis.".Lipids in health and disease 18..1(2019):124