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Significance of tertiary Gleason pattern 5 in patients with Gleason score 7 after radical prostatectomy: a retrospective cohort study.

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机构： [1]Department of Urology, Institute of Urology, Center of Biomedical Bid Data and National Clinical Research Center of Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China [2]Department of Urology, Chongqing Three Gorges Central Hospital, Chongqing 404000, People’s Republic of China

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关键词： prostate cancer biochemical recurrence Gleason score tertiary Gleason pattern radical prostatectomy

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To evaluate the association between tertiary Gleason pattern 5 (TGP5) and biochemical recurrence (BCR) in patients with prostate cancer (PCa) with a Gleason score (GS) of 7 after radical prostatectomy (RP). This retrospective study identified 350 patients who received RP and were graded as GS 7 (3+4 or 4+3) at the West China Hospital from January 2009 to December 2017. Initially, the patients were divided into two groups, TGP5 absence and TGP5 presence, independent of Gleason score. We further stratified the patients by adding the Gleason score into four groups: GS 3+4, GS 3+4/TGP5, GS 4+3, and GS 4+3/TGP5. Cox proportional-hazards models were used to evaluate the association between the status of TGP5 and BCR after adjusting for the confounding factors. The risk of BCR was significantly higher in patients with TGP5 when compared to patients without TGP5 (P=0.04, HR=2.17 95%, Cl: 1.03-4.59). For patients with primary Gleason pattern 4, the risk of BCR for patients with Gleason 4+3/TGP5 was statistically significantly higher than Gleason 4+3 (P=0.04, HR=2.45, 95% Cl: 1.04-5.76). The TGP5 in patients with GS 7 had strong association with the risk of BCR and was an independent predictor for BCR. Further research on larger data sets is needed to confirm these findings. © 2019 Li et al.

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区生物工程与应用微生物 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 3 区生物工程与应用微生物 4 区肿瘤学

第一作者：

第一作者机构： [1]Department of Urology, Institute of Urology, Center of Biomedical Bid Data and National Clinical Research Center of Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China

通讯作者：

通讯机构： [1]Department of Urology, Institute of Urology, Center of Biomedical Bid Data and National Clinical Research Center of Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China [*1]Department of Urology, Institute of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan 610041, People’s Republic of China

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