机构：[1]Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.四川大学华西医院[2]West China School of Medicine, Sichuan University, Chengdu, China.四川大学华西医院[3]The Third People's Hospital of Chengdu, Chengdu, China.
This study aims to determine the prognostic value of preoperative Naples prognostic score (NPS) on survival outcomes in upper tract urothelial carcinoma (UTUC) patients after radical nephroureterectomy (RNU). We conducted a retrospective study about UTUC patients at West China Hospital from January 2015 to June 2019. The X-Tile program was used to identify the optimal cutoff value of NPS. Overall survival (OS), cancer-specific survival (CSS) and progression-free survival (PFS) were the endpoints of interest. Kaplan-Meier curves were used to estimate survival and Cox proportional hazard model was used for risk assessment. A total of 237 UTUC patients after RNU were identified and the threshold of NPS was determined to be 2. Preoperative high-NPS was associated with inferior OS (p = 0.004), CSS (p = 0.002) and PFS (p = 0.008), especially in locally advanced UTUC patients. Preoperative NPS was an independent predictor for OS (HR: 1.78; 95% CI: 1.08, 2.93), CSS (HR: 1.87; 95% CI: 1.11, 3.14) and PFS (HR: 1.60; 95% CI: 1.02, 2.50). The addition of NPS into the predictive model consisting of predictors from multivariate Cox regression resulted in better prediction performance. Preoperative NPS was a novel and reliable predictor for survival in UTUC patients after RNU, and should be further explored.
基金：
This work was supported by the National Natural Science Foundation of China (Grant number: 81500522) and Science & Technology Department of Sichuan Province (Grant number: 2020YFS0090, 2020YFS0046).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|4 区医学
小类|4 区营养学4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区营养学4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.[2]West China School of Medicine, Sichuan University, Chengdu, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ye Jianjun,Chen Zeyu,Pan Yulong,et al.The Prognostic Value of Preoperative Naples Prognostic Score in Upper Tract Urothelial Carcinoma Patients after Radical Nephroureterectomy[J].Nutrition and cancer.2023,1-9.doi:10.1080/01635581.2023.2279218.
APA：
Ye Jianjun,Chen Zeyu,Pan Yulong,Liao Xinyang,Wang Xingyuan...&Bao Yige.(2023).The Prognostic Value of Preoperative Naples Prognostic Score in Upper Tract Urothelial Carcinoma Patients after Radical Nephroureterectomy.Nutrition and cancer,,
MLA：
Ye Jianjun,et al."The Prognostic Value of Preoperative Naples Prognostic Score in Upper Tract Urothelial Carcinoma Patients after Radical Nephroureterectomy".Nutrition and cancer .(2023):1-9
