机构：[a]Laboratory of Molecular Pharmacology,Department of Pharmacology,School of Pharmacy,Southwest Medical University,Luzhou 646000, China[b]Department of Gastroenterology,Shenzhen Hospital,Southern Medical University,Shenzhen518000,China南方医科大学深圳医院深圳市康宁医院深圳医学信息中心[c]Sichuan Industrial Institute of Antibiotics,Chengdu University,Chengdu610106,China[d]Department of Gastrointestinal Surgery,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,China[e]Department of Anaesthesia and Intensive Care,The Chinese University of HongKong,HongKong,China[f]State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao, China
Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components. Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, we summarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent.
基金：
This work was supported by the National Natural Science Foundation of China (Nos. 81770562, 81602166 and 81703807) and grants from the Science and Technology Planning Project of Luzhou, Sichuan Province, China (Nos. 2016LZXNYD-Z04 and 2017LZXNYD-J02).
第一作者机构：[a]Laboratory of Molecular Pharmacology,Department of Pharmacology,School of Pharmacy,Southwest Medical University,Luzhou 646000, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Xu Wu,Wei Hu,Lan Lu,et al.Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment.[J].ACTA PHARMACEUTICA SINICA B.2019,9(2):203-219.doi:10.1016/j.apsb.2018.09.002.
APA：
Xu Wu,Wei Hu,Lan Lu,Yueshui Zhao,Yejiang Zhou...&Mingxing Li.(2019).Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment..ACTA PHARMACEUTICA SINICA B,9,(2)
MLA：
Xu Wu,et al."Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment.".ACTA PHARMACEUTICA SINICA B 9..2(2019):203-219
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