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A therapeutic HPV16 E7 vaccine in combination with active anti-FGF-2 immunization synergistically elicits robust antitumor immunity in mice.

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机构: [a]Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming, China [b]Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease [c]Sichuan Institute for Food and Drug Control, Chengdu, China [d]Yunnan Center for Disease Control and Prevention, Kunming, China [e]Department of Burn, The Second Affiliated Hospital, Kunming Medical University,Kunming, China
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关键词: Virus-like particle (VLP) Fibroblast growth factor-2 (FGF-2) Anti-cytokine active immunization Therapeutic vaccine Human papillomavirus (HPV)

摘要:
FGF-2 accumulates in many tumor tissues and is closely related to the development of tumor angiogenesis and the immunosuppressive microenvironment. This study aimed to investigate whether active immunization against FGF-2 could modify antitumor immunity and enhance the efficacy of an HPV16 E7-specific therapeutic vaccine. Combined immunization targeting both FGF-2 and E7 significantly suppressed tumor growth,which was accompanied by significantly increased levels of IFN-γ-expressing splenocytes and effector CD8 T cells and decreased levels of immunosuppressive cells such as regulatory T cells(Tregs) and myeloid-derived suppressor cells(MDSCs) in both the spleen and tumor; in addition,the levels of FGF-2 and neovascularization in tumors were decreased in the mice receiving the combined immunization, and tumor cell apoptosis was promoted.The combination of an HPV16 E7-specific vaccine and active immunization against FGF-2 significantly enhances antitumor immune responses in mice with TC-1 tumors, indicating a promising strategy for tumor immunotherapy. Copyright © 2020. Published by Elsevier Inc.

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出版当年[2020]版:
大类 | 2 区 医学
小类 | 2 区 纳米科技 2 区 医学:研究与实验
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 医学:研究与实验 3 区 纳米科技
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第一作者机构: [a]Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming, China [b]Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease
通讯作者:
通讯机构: [a]Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming, China [b]Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease [*1]Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming, China.
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