机构：[1]Department of Infection Management, The People’s Hospital of Jianyang City, Chengdu, Sichuan Province, China[2]Department of Gastroenterology, Medical Centre of Dujiangyan City, Chengdu, Sichuan Province, China[3]Department of Endocrinology, The People’s Hospital of Jianyang City, Chengdu, Sichuan Province, China[4]Department of Infection Management, Sichuan Provincial Fourth People’s Hospital, Chengdu, Sichuan Province, China[5]Department of Central Laboratory, The People’s Hospital of Jianyang City, Chengdu, Sichuan Province, China[6]Department of Laboratory Medicine, Chengdu Second People’s Hospital, Chengdu, Sichuan Province, China[7]Institute of Liver Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China
To investigate adipocytokine expression levels, platelet-to-lymphocyte ratio (PLR) and transforming growth factor (TGF)-β1/Smad signaling activity in diabetic patients with pulmonary infection.
Eighty-two type 2 diabetic patients with pulmonary infection were included in the observation group and 75 patients with simple type 2 diabetes were recruited into the control group. The fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and PLR in the two groups were compared. Complement-C1q/tumor necrosis factor related protein 3 (CTRP-3), complement-C1q/tumor necrosis factor related protein 9 (CTRP-9), leptin, adiponectin, and TGF-β1/Smad signaling pathway activity in peripheral blood mononuclear cells (PBMCs) was detected.
Compared with patients in the control group, patients in the observation group presented with increased levels of FGB, HbA1c, and leptin, an increase in the PLR, and decreased serum CTRP-3, CTRP-9, and adiponectin levels. TGF-β1, p-Smad2, and p-Smad3 protein expression levels were up-regulated in PBMCs from patients in the observation group compared with the control group.
These results show that in type 2 diabetic patients with pulmonary infection, adipocytokine expression is altered, PLR is disturbed, and the TGF-β1/Smad signaling pathways in PBMCs are significantly activated.
基金：
This research was funded by the Sichuan
Province Preventive Medicine Research Fund
Project (SCJK2016007) to improve the neonatal
room table cleaning effect in applied research.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
第一作者：
第一作者机构：[1]Department of Infection Management, The People’s Hospital of Jianyang City, Chengdu, Sichuan Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Infection Management, The People’s Hospital of Jianyang City, Chengdu, Sichuan Province, China[*1]Department of Infection Management, The People’s Hospital of Jianyang City, No. 180 Yiyuan Road, Jianyang, Chengdu 641400, Sichuan Province, China.
推荐引用方式(GB/T 7714)：
Mei Zha,Xiao-Bing Ren,Jing Chen,et al.Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-β1/Smad signaling activity in diabetic patients complicated with pulmonary infection.[J].The Journal of international medical research.2020,48(6):300060520926006.doi:10.1177/0300060520926006.
APA：
Mei Zha,Xiao-Bing Ren,Jing Chen,Ying Fang,Ping Yu...&Ting-Wei Gou.(2020).Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-β1/Smad signaling activity in diabetic patients complicated with pulmonary infection..The Journal of international medical research,48,(6)
MLA：
Mei Zha,et al."Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-β1/Smad signaling activity in diabetic patients complicated with pulmonary infection.".The Journal of international medical research 48..6(2020):300060520926006
