机构：[a]Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China,[b]Department of Biomedicine, Chengdu Medical College,[c]Sichuan Cancer Hospital and Institute, Chengdu,四川省肿瘤医院[d]Department of Bioinformatics, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
Breast cancer is now the leading cause of cancer death in women worldwide. Cancer progression is driven not only by cancer cell intrinsic alterations and interactions with tumor microenvironment, but also by systemic effects. Integration of multiple profiling data may provide insights into the underlying molecular mechanisms of complex systemic processes. We performed a bioinformatic analysis of two public available microarray datasets for breast tumor stroma and peripheral blood mononuclear cells, featuring integrated transcriptomics data, protein-protein interactions (PPIs) and protein subcellular localization, to identify genes and biological pathways that contribute to dialogue between tumor stroma and the peripheral circulation. Genes of the integrin family as well as CXCR4 proved to be hub nodes of the crosstalk network and may play an important role in response to stroma-derived chemoattractants. This study pointed to potential for development of therapeutic strategies that target systemic signals travelling through the circulation and interdict tumor cell recruitment.
基金：
Funding statement. This work was supported by the National Natural Science Foundation of China (grant no.81201702). Health and Family Planning Commission of Sichuan Province of China (grant no.120491; no.130295). Science and technology support program of Sichuan Science and Technology Department (grant no.2016GZ0364).
语种：
外文
第一作者：
第一作者机构：[a]Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China,[b]Department of Biomedicine, Chengdu Medical College,
通讯作者：
通讯机构：[a]Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China,[b]Department of Biomedicine, Chengdu Medical College,
推荐引用方式(GB/T 7714)：
He L,Wang D,Wei N,et al.Integrated bioinformatics approach reveals crosstalk between tumor stroma and peripheral blood mononuclear cells in breast cancer(Open Access)[J].Asian Pacific Journal of Cancer Prevention.2016,17(3):doi:10.7314/APJCP.2016.17.3.1003.
APA：
He, L,Wang, D,Wei, N&Guo, Z.(2016).Integrated bioinformatics approach reveals crosstalk between tumor stroma and peripheral blood mononuclear cells in breast cancer(Open Access).Asian Pacific Journal of Cancer Prevention,17,(3)
MLA：
He, L,et al."Integrated bioinformatics approach reveals crosstalk between tumor stroma and peripheral blood mononuclear cells in breast cancer(Open Access)".Asian Pacific Journal of Cancer Prevention 17..3(2016)
